用于UHDR单电子脉冲监测的碳化硅探测器和光束电流互感器信号的系统研究。

IF 2.5 3区 医学 Q2 BIOLOGY
C Okpuwe, G Milluzzo, D Coves, T Delaviere, D Del Sarto, M De Napoli, F Di Martino, G Felici, L Lanzanò, L Masturzo, J Pensavalle, E Touzain, M Camarda, F Romano
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引用次数: 0

摘要

使用超高剂量率光束(UHDR) (> 40 Gy/s)进行放射治疗,尽管具有显示FLASH效应的优势,可以改善健康组织的保护,但在剂量学和光束监测方面面临挑战,因为电离室等标准剂量计在如此高的剂量率下会经历饱和效应。碳化硅(SiC)探测器最近被证明具有剂量率无关的低能量脉冲电子束,瞬时剂量率可达5.5 MGy/s,并且已成为FLASH-RT剂量测定的可靠替代技术。本研究探讨了使用SiC探测器测量脉冲内瞬时剂量率的适用性,这是监测UHDR脉冲电子束脉冲内波动所必需的。实验报告是使用由ElectronFlash直线加速器加速的9 MeV的UHDR电子束进行的,并使用不同的光束参数,如光束电流(即每个脉冲的不同剂量)和脉冲宽度设置。使用10µm厚、4.5 mm2面积的不同配置的SiC探测器测量时域单脉冲形状信号,并与表征良好的交流电流互感器(ACCT)(作为加速器的标准监测系统)进行比较,并将第二个ACCT放置在与SiC探测器相同的位置(即在照射点的涂抹器之后)。结果表明,SiC探测器和ACCT的信号在照射点周围放置在施放器后的高度一致。这强调了SiC探测器和ACCT用于监测脉冲内瞬时剂量率的潜力。此外,由于SiC探测器和ACCT的使用基于不同的物理原理,它们可以提供互补的光束信息。两者的结合有可能为UHDR光束提供各种感兴趣的变量。然而,当将SiC信号与安装在LINAC中的ACCT进行比较时,观察到一些差异,这些差异随着每脉冲剂量的降低而线性增加。需要进一步的研究来更好地理解这些观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic Study of Silicon Carbide Detectors and Beam Current Transformer Signals for UHDR Single Electron Pulse Monitoring.

The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage of exhibiting the FLASH effect that improves the sparing of healthy tissues, faces challenges in dosimetry and beam monitoring since standard dosimeters like the ionization chamber experience saturation effects at such high dose rates. Silicon carbide (SiC) detectors have recently been demonstrated to be dose-rate independent with low-energy pulsed electron beams up to an instantaneous dose rate of 5.5 MGy/s, and has emerged as a reliable alternative technology for dosimetry in FLASH-RT. This study explored the suitability of using the SiC detector for measuring intra-pulse instantaneous dose rates, which are necessary for monitoring fluctuations within the pulse of UHDR pulsed electron beams. The experiments reported were conducted using UHDR electron beams accelerated at 9 MeV by an ElectronFlash linac and using varying different beam parameters, such as the beam current (i.e., different dose per pulse) and pulse width settings. The temporal single pulse shape signals were measured with a 10 µm thick, 4.5 mm2 area SiC detector for different configurations and compared with a well-characterized AC current transformer (ACCT) (which served as the standard monitoring system of the accelerator), and with a second ACCT placed at the same location as the SiC detector (i.e., after the applicator at the irradiation point). The results show a high level of agreement between the signals of the SiC detector and ACCT placed after the applicator at around the irradiation point. This underscores the potential of the SiC detector and the ACCT to be used for monitoring instantaneous dose rates within a pulse. Furthermore, since use of the SiC detector and ACCT are based on different physical principles, they can provide complementary beam information. A combination of the two has the potential to provide insight about a variety of variables of interest for UHDR beams. However, some discrepancies were observed when comparing the SiC signals with the ACCT installed in the LINAC, which increased linearly with decreasing dose per pulse. Further studies are required to better understand these observations.

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来源期刊
Radiation research
Radiation research 医学-核医学
CiteScore
5.10
自引率
8.80%
发文量
179
审稿时长
1 months
期刊介绍: Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.
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