一例由红酵母米补充剂引起的急性肾损伤和范可尼综合征病例

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-22 DOI:10.2169/internalmedicine.4330-24

Toshiki Doi, Akira Shimizu, Emi Morimoto, Kenichi Morii, Aiko Okubo, Sonoo Mizuiri, Yoshiko Nishizawa, Takao Masaki

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引用次数: 0

摘要

我们在此报告一例急性肾损伤和范可尼综合征与红曲米补充。一名72岁女性在开始补充后血清肌酐由0.7 mg/dL上升至3.97 mg/dL，并伴有代谢性酸中毒、蛋白尿、血尿、血糖升高。肾活检显示近端小管损伤，无明显小管炎。免疫染色显示CD10阳性的扩张小管，证实近端小管定位。停止补充和类固醇脉冲治疗改善了患者的病情。这一案例突出了与不受管制的膳食补充有关的健康风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Acute Kidney Injury and Fanconi Syndrome Caused by a Red Yeast Rice Supplement.

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Acute Kidney Injury and Fanconi Syndrome Caused by a Red Yeast Rice Supplement.

We herein report a case of acute kidney injury and Fanconi syndrome associated with a red yeast rice supplement. A 72-year-old woman's serum creatinine rose from 0.7 to 3.97 mg/dL after starting the supplement, accompanied by metabolic acidosis, proteinuria, hematuria, and glucosuria. A kidney biopsy showed proximal tubular injury without abundant tubulitis. Immunostaining showed dilated tubules that were positive for CD 10, confirming proximal tubule localization. Discontinuation of the supplement and steroid pulse therapy improved the patient's condition. This case highlights the health risks associated with unregulated dietary supplementation.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.