肾有机阴离子转运蛋白1：慢性肾脏疾病的临床相关性和潜在机制。

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2025-02-24 DOI:10.1186/s12882-025-03974-y

Changfang You, Jianchun Guo, Yunhao Xun

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引用次数: 0

摘要

有机阴离子转运蛋白1 （OAT1）主要存在于肾近端小管中，对各种尿毒症毒素的排泄至关重要，这些毒素有助于慢性肾脏疾病（CKD）的发生和进展。OAT1在遥感和信号网络中也起着至关重要的作用，促进代谢产物通过肾脏的清除。在肾缺血/再灌注损伤、氧化应激和纤维化等情况下，OAT1的功能受损。几种转录因子、翻译后修饰和内分泌激素控制着OAT1的活性和表达。这篇综述探讨了OAT1对ckd相关ut排泄的独特贡献及其机制。

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Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease.

Organic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD). OAT1 also plays a vital role in the remote sensing and signaling network, facilitating the removal of metabolites through the kidneys. The function of OAT1 is impaired under conditions such as renal ischemia/reperfusion injury, oxidative stress, and fibrosis. Several transcription factors, post-translational modifications, and endocrine hormones control the activity and expression of OAT1. This review explores the unique contribution of OAT1 to the excretion of CKD-related UTs and the mechanisms involved.

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.