体内细胞对LNPs反应的时间过程。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-02-25 DOI:10.1039/d4cc06659f

David Loughrey , Kalina Paunovska , Elisa Schrader Echeverri , Karen E. Tiegreen , James E. Dahlman

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引用次数: 0

摘要

细胞对药物输送系统有积极反应。然而，细胞对脂质纳米颗粒（LNPs）反应的时间过程仍不清楚。在这里，我们描述了在体内不同时间点对携带mRNA的LNPs的转录组反应。LNPs暴露在给药后一小时内改变了信号通路的表达，包括内吞作用和溶酶体途径。这些通路在24小时后恢复到基线状态。我们的数据与细胞主动但短暂地对LNPs作出反应的假设是一致的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The time course of in vivo cellular responses to LNPs†

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The time course of in vivo cellular responses to LNPs†

Cells actively respond to drug delivery systems. However, the time course of cellular responses to lipid nanoparticles (LNPs) remains unclear. Here we characterized the transcriptomic response to LNPs carrying mRNA at different timepoints in vivo. Exposure to LNPs altered the expression of signaling pathways including endocytosis and lysosomal pathways as soon as one hour after administration. These pathways returned to their baseline state by 24 hours. Our data are consistent with the hypothesis that cells actively yet transiently respond to LNPs.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.