噬菌体尾状细菌素的世界：技术现状和生物技术的观点

IF 6.1 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2025-02-25 DOI:10.1016/j.micres.2025.128121

Clara Ibarguren , Inés Bleriot , Lucia Blasco , Laura Fernández-García , Concha Ortiz-Cartagena , Lucia Arman , Antonio Barrio-Pujante , Olaya Menéndez Rodríguez , Rodolfo García-Contreras , Thomas K. Wood , María Tomás

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引用次数: 0

摘要

在争夺资源的过程中，细菌发展出了不同的竞争系统，包括VI型分泌系统（T6SS）和噬菌体尾状细菌素（PTLBs），它们通过杀死其他细菌物种或来自同一物种的菌株来起作用。抗菌素耐药性（AMR）的出现是一个紧迫的全球卫生问题。在这种情况下，开发新的抗菌药物的需要使PTLBs成为人们关注的焦点。本文对ptlb的结构特征、生物学特性、应用技术手段以及专利等方面进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The world of phage tail-like bacteriocins: State of the art and biotechnological perspectives

In the struggle for resources, bacteria have developed different systems of competition, including the type VI secretion system (T6SS) and phage tail-like bacteriocins (PTLBs), that act by killing other bacterial species or strains from the same species. The emergence of antimicrobial resistance (AMR) is an urgent global health problem. In this context, the need to develop new antimicrobial agents has put PTLBs in the spotlight. This review focuses on the most relevant aspects of PTLBs such as their structural features, biology, the technological tools to improve their application, and the most importantly their patents.

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.