从化疗诱导的周围神经病变（CIPN）和化疗后认知障碍（PCCI）患者中获得10种人诱导多能干细胞系（hiPSCs）

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-02-09 DOI:10.1016/j.scr.2025.103674

Karyn Lewis , Valeria Fernandez Vallone , Adam Dordevic , Johannes Kern , Harald Stachelscheid , Matthias Endres , Wolfgang Boehmerle , Petra Huehnchen , Christian Schinke

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引用次数: 0

摘要

化疗引起的周围神经病变（CIPN）和化疗后认知障碍（PCCI）是化疗的主要副作用。利用仙台病毒载体，从接受化疗、发生或未发生CIPN和PCCI的患者中产生了10个hiPSC系。对每系进行鉴定，以确定未分化状态、分化潜力、基因组完整性、身份验证和重编程载体去除的标记。这些细胞系是创建两种疾病模型的宝贵资源：1)CIPN（来自5名CIPN患者的hiPSC细胞系与5名无CIPN患者的hiPSC细胞系）和2)PCCI（来自4名PCCI患者的hiPSC细胞系与5名无PCCI患者的hiPSC细胞系）。

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Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI)

Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. Each line was characterized to confirm markers of the undifferentiated state, differentiation potential, genomic integrity, identity verification and reprogramming vector removal. These lines serve as a valuable resource to create two disease models for 1) CIPN (hiPSC lines from five patients with CIPN vs. five without CIPN) and 2) PCCI (hiPSC lines from four patients with PCCI vs. five without PCCI).

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.