动态光学乳腺成像（DOBI）对乳腺癌恶性特征诊断的有效性

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2025-02-26 DOI:10.1016/j.jrras.2025.101328

Tong Hu , Jianguo Chen , Lili Qiao , Yaner Gu

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引用次数: 0

摘要

目的探讨动态光学乳腺成像技术（DOBI）对乳腺癌恶性特征的诊断价值。方法对213例乳腺疾病患者行DOBI检查，一周内行超声引导下空核穿刺活检。分析DOBI对不同病变大小的乳腺肿块和不同病理类型的乳腺癌的诊断准确性。结果病理活检发现恶性病变20例，良性病变193例。良性病例共检出247个病灶，恶性病例共检出24个病灶。DOBI对直径≤1 cm、1 - 2 cm和≥2 cm的乳腺肿块的诊断准确率分别为82.35%、82.83%和87.60%。对于浸润性导管癌、导管原位癌和浸润性小叶癌，DOBI的诊断准确率分别为53.85%、60.00%和33.33%。以乳腺穿刺活检为金标准，确定DOBI诊断乳腺癌的敏感性为80.00%，特异性为84.21%，误诊率为15.03%，漏诊率为20.00%，曲线下面积为0.862 （95% CI: 0.613-0.978）。结论dobi在诊断乳腺癌恶性特征方面具有良好的应用前景，为早期诊断和治疗提供了有效依据。

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Validity of dynamic optical breast imaging (DOBI) in diagnosis of malignant features of breast cancer

Objective

To investigate the effectiveness of dynamic optical breast imaging technology (DOBI) in diagnosing malignant features of breast cancer.

Methods

213 patients with breast diseases underwent DOBI examination followed by ultrasound-guided hollow-core needle aspiration biopsy within one week. Diagnostic accuracy of DOBI for breast masses of different lesion sizes and breast cancers of different pathological types was analyzed.

Results

Pathological biopsy identified 20 malignant lesions and 193 benign lesions among the study participants. A total of 247 lesions were detected in benign cases, while 24 lesions were detected in malignant cases. The diagnostic accuracies of DOBI for breast masses with diameters ≤1 cm, 1–2 cm, and ≥2 cm were found to be 82.35%, 82.83%, and 87.60%, respectively. For invasive ductal carcinoma, ductal carcinoma in situ, and invasive lobular carcinoma, DOBI exhibited diagnostic accuracies of 53.85%, 60.00%, and 33.33%, respectively. Using breast puncture biopsy as gold standard, the sensitivity, specificity, misdiagnosis rate, missed diagnosis rate, and area under the curve of DOBI in diagnosing breast cancer were determined as 80.00%, 84.21%, 15.03%, 20.00%, and 0.862 (95% CI: 0.613–0.978), respectively.

Conclusion

DOBI holds promising application prospects in diagnosing malignant features of breast cancer, providing an effective basis for early diagnosis and treatment.

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.