钙信号是辅助性T细胞分化所必需的

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-02-25 DOI:10.1038/s41590-025-02101-1

引用次数: 0

摘要

CD4+辅助性T细胞中储存操作的钙进入对转录因子NFAT的激活至关重要，NFAT促进T辅助性1细胞谱系决定转录因子T-bet的表达。我们发现NFAT与干扰素诱导的STAT1协同作用，在缺乏IL-12信号的情况下驱动T-bet表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Calcium signaling is essential for T helper 1 cell differentiation

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Calcium signaling is essential for T helper 1 cell differentiation

Store-operated calcium entry in CD4+ T helper cells is essential for activation of the transcription factor NFAT, which promotes expression of the T helper 1 cell-lineage-determining transcription factor T-bet. We show that NFAT synergizes with interferon-induced STAT1 to drive T-bet expression in the absence of IL-12 signaling.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.