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引用次数: 0
摘要
目的：通过荟萃分析探讨经颅直流电刺激（tDCS）治疗强迫症（OCD）的疗效和安全性。方法：于23年6月25日检索Cochrane、PubMed、Embase、Web of Science 4个电子数据库。从我们的纳入标准中，纳入了7项研究（N = 201例患者），我们使用Stata15.0进行了荟萃分析。结果：结果显示强迫症患者经tDCS治疗后Y-BOCS （Yale-Brown强迫症量表）总分明显降低[SMD= -0.46, 95%CI (-0.84, -0.07), I2=39%, p = 0.02，等级：高]。亚组分析显示，治疗时间≤20 d时，结果具有统计学意义[SMD= -0.95, 95%CI (-1.80, -0.10), p = 0.03]。此外，tDCS与假tDCS治疗强迫症患者的抑郁症状无显著差异，不良事件也无显著差异[RR= -0.21, 95%CI (-0.58, 0.15), p = 0.25，分级：中度]和[RR= 3.98, 95%CI (0.04, 374.99), p = 0.55，分级：极低]。结论：tDCS可降低强迫症患者的Y-BOCS总分和抑郁症状，但对不良反应无显著影响。结果尚无定论。
Transcranial direct current stimulation in patients with obsessive-compulsive disorder: a meta-analysis of randomised controlled trials.
Objective: Efficacy and safety of transcranial direct current stimulation (tDCS) in the treatment of obsessive-compulsive disorder (OCD) were explored by meta-analysis.
Method: Four electronic databases (Cochrane, PubMed, Embase, Web of Science) were retrieved at 25/06/23. From our inclusion criteria, seven studies (N = 201 patients) were included, and we performed a meta-analysis using Stata15.0.
Results: Results suggested that the total Y-BOCS (Yale-Brown obsessive com-pulsive scale) scale was significantly lower in patients with OCD after tDCS treatment [SMD= -0.46, 95%CI (-0.84, -0.07), I2=39%, p = 0.02, Grade: high]. Subgroup analysis showed statistically significant results when treatment duration ≤ 20 days [SMD= -0.95, 95%CI (-1.80, -0.10), p = 0.03]. Moreover, tDCS and sham tDCS-treated OCD patients showed neither significantly different depressive symptoms nor significantly different adverse events [RR= -0.21, 95%CI (-0.58, 0.15), p = 0.25, Grade: moderate] and [RR = 3.98, 95%CI (0.04, 374.99), p = 0.55, Grade: very low], respectively.
Conclusion: tDCS maybe reduce the Y-BOCS total scores in OCD patients and depressive symptoms, but for adverse reactions. the results are inconclusive.
期刊介绍：
International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry.
The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice.
Focus on the practical aspects of managing and treating patients.
Essential reading for the busy psychiatrist, trainee and interested physician.
Includes original research papers, comprehensive review articles and short communications.
Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.
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