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IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1470747

Chenyu Fan, Hanfei Li, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li

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引用次数: 0

摘要

目的：本研究利用功能性近红外光谱（fNIRS）研究了轻度认知障碍（MCI）患者和无认知障碍患者（健康对照组，HCs）在完成Stroop任务时大脑激活模式的差异：我们利用 fNIRS 分析了 73 名 MCI 患者和 63 名健康对照者在完成 Stroop 任务时的大脑皮层激活模式。感兴趣区（ROI）包括背侧前额叶皮层（dPFC）、腹外侧前额叶皮层（VLPFC）和顶叶（PL）。Stroop 任务分为早期阶段（0-15 秒）和晚期阶段（15-30 秒）。我们还测量了参与者在Stroop任务中的行为，分析了不同实验阶段皮层激活强度的变化，并对蒙特利尔认知评估（MoCA）得分、Stroop表现和氧合水平进行了相关分析：我们的分析表明，MCI和HC患者在执行Stroop任务时，dPFC、VLPFC和PL区域的皮质激活强度升高（q < 0.05，FDR校正）。与 HC 组相比，MCI 组的反应潜伏期更长，但在相同和不相同的 Stroop 试验中表现出了相当的准确性。与 HC 组相比，MCI 组在 Stroop 任务的后期阶段表现出 VLPFC 和 PL 区域的补偿性激活（q < 0.05，FDR 校正）。相关分析表明，在 Stroop 任务的后期阶段，MoCA 评分与 dPFC、VLPFC 和 PL 区域的氧合水平呈负相关（p < 0.05）。结论：轻度认知障碍患者的行为表现与血氧饱和度呈负相关：结论：轻度认知障碍患者在执行 Stroop 任务时，通过对前额叶和顶叶区域进行补偿性激活，在部分行为层面对其认知障碍进行了有效补偿。

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Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study.

Purpose: This study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).

Methods: We analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). The Stroop task is divided into early stage (0-15 s) and late stage (15-30 s). We also measured participants' behavior during the Stroop task, analyzed variations in cortical activation intensity at different experiment stages, and performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, Stroop performance, and oxygenation levels.

Results: Our analysis revealed that individuals with MCI and HC demonstrated elevated cortical activation in the dPFC, VLPFC, and PL areas while performing the Stroop task (q < 0.05, FDR-corrected). The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. The MCI group showed compensatory activation in the VLPFC, and PL regions compared to the HC group during the late stage of the Stroop task (q < 0.05, FDR-corrected). Correlational analysis revealed a negative association between MoCA scores and oxygenation levels in the dPFC, VLPFC, and PL regions during the late stage of the Stroop task (p < 0.05). However, no correlation was found with behavioral performance.

Conclusion: Mild cognitive impairment patients demonstrated effective compensation for their cognitive impairments at a partial behavioral level by engaging compensatory activation in the prefrontal, and parietal regions while performing the Stroop task.

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.