CAR - t细胞治疗后非典型髓系肉瘤的FDG PET/CT分析。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-06-01 Epub Date: 2025-02-24 DOI:10.1097/RLU.0000000000005759

Daniel L Gray, Joanna Fair

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引用次数: 0

摘要

一名23岁男性，有ph样b细胞急性淋巴细胞白血病（B-ALL）病史，伴有JAK2重排，在1周内出现无数皮肤病变。在此之前，他的B-ALL多次复发，并接受了自体UCD-19嵌合抗原受体（CAR） t细胞治疗。病灶在治疗结束后1.5个月出现。活检显示新发髓样肉瘤（MS）， B-ALL持续缓解。18F-FDG PET/CT显示大量明显的高代谢软组织病变位于皮肤和皮下组织、肌肉、骨结构、粘膜、胸膜、纵隔、腹膜、腹膜后和睾丸。

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FDG PET/CT of Atypical Myeloid Sarcoma After CAR T-Cell Therapy.

A 23-year-old man with a history of Ph-Like B-cell acute lymphoblastic leukemia (B-ALL) with JAK2 rearrangement presented with innumerable skin lesions developing over 1 week. Before presentation, he had multiple relapses of his B-ALL and underwent autologous UCD-19 chimeric antigen receptor (CAR) T-cell therapy. Lesions appeared 1.5 months after completion of therapy. Biopsies showed new onset myeloid sarcoma (MS), with continued remission of B-ALL. 18 F-FDG PET/CT showed numerous markedly hypermetabolic soft tissue lesions located in the skin and subcutaneous tissues, muscles, osseous structures, mucosa, pleura, mediastinum, peritoneum, retroperitoneum, and testes.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.