增长的一维域上反应-扩散模式的尖峰自复制和尖峰成核的渐近分析。

IF 2 4区 数学 Q2 BIOLOGY
Chunyi Gai, Edgardo Villar-Sepúlveda, Alan Champneys, Michael J Ward
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引用次数: 0

摘要

在大扩散比的渐近极限下,某些双组分反应扩散系统在一维有限域上的非平衡非线性区域上可以存在局域尖峰解。已知当畴半长L缓慢增加时,会出现两种不同的分叉机制,产生空间复杂性增加的尖峰模式;所谓的穗核和穗自我复制。发现自我复制发生通过通道超过一个鞍节点分岔点,可以预测通过线性化周围的内尖峰轮廓。相反,在非线性边值问题的鞍节点以外的区域定义的非线性边值问题,在远离穗状核的外部区域缓慢通过时,穗状核发生。这里,通过将L作为拉格朗日框架下的静态参数,在半强相互作用渐近区域内建立了精确的条件来确定发生了什么,这些条件通过数值模拟和延演得到了证实。对于Schnakenberg和Brusselator RD模型,导出了参数空间中的相图,预测随着L的增加,是否会首先发生尖峰自复制或尖峰成核,或者是否不会发生这种不稳定性。对于具有非平凡激活剂背景的Gierer-Meinhardt模型,证明了刺核成核是唯一可能的刺核产生机制。从指数缓慢增长区域上随时间变化的偏微分方程数值结果表明,由渐近理论导出的解析阈值准确地预测了L的临界值,在该临界值下,峰值自复制或峰值成核将发生。在以L为主要分岔参数的尖峰平衡的数值计算解分支上叠加时变PDE模拟结果,进一步阐明了向空间复杂度增加模式过渡的全局分岔机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Asymptotic Analysis of Spike Self-Replication and Spike Nucleation of Reaction-Diffusion Patterns on Growing 1-D Domains.

In the asymptotic limit of a large diffusivity ratio, certain two-component reaction-diffusion (RD) systems can admit localized spike solutions on a one-dimensional finite domain in a far-from-equilibrium nonlinear regime. It is known that two distinct bifurcation mechanisms can occur which generate spike patterns of increased spatial complexity as the domain half-length L slowly increases; so-called spike nucleation and spike self-replication. Self-replication is found to occur via the passage beyond a saddle-node bifurcation point that can be predicted through linearization around the inner spike profile. In contrast, spike nucleation occurs through slow passage beyond the saddle-node of a nonlinear boundary-value problem defined in the outer region away from the core of a spike. Here, by treating L as a static parameter under the Lagrangian framework, precise conditions are established within the semi-strong interaction asymptotic regime to determine which occurs, conditions that are confirmed by numerical simulation and continuation. For the Schnakenberg and Brusselator RD models, phase diagrams in parameter space are derived that predict whether spike self-replication or spike nucleation will occur first as L is increased, or whether no such instability will occur. For the Gierer-Meinhardt model with a non-trivial activator background, spike nucleation is shown to be the only possible spike-generating mechanism. From time-dependent PDE numerical results on an exponentially slowly growing domain, it is shown that the analytical thresholds derived from the asymptotic theory accurately predict critical values of L where either spike self-replication or spike-nucleation will occur. The global bifurcation mechanism for transitions to patterns of increased spatial complexity is further elucidated by superimposing time-dependent PDE simulation results on the numerically computed solution branches of spike equilibria in which L is the primary bifurcation parameter.

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来源期刊
CiteScore
3.90
自引率
8.60%
发文量
123
审稿时长
7.5 months
期刊介绍: The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.
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