胰腺脂肪变性是胰腺导管腺癌的风险因素:发病机制和临床意义。

IF 3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Zoi Papalamprakopoulou, Prasenjit Dey, Rachel Frascati, Christos Fountzilas
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引用次数: 0

摘要

摘要:胰腺脂肪变性是指胰腺内脂肪的异位堆积。虽然历史上被认为是良性的偶然影像学发现,但现在被认为是独立于肥胖的胰腺导管腺癌(PDAC)的重要且潜在可逆的危险因素。虽然其流行病学特征尚不明确,但荟萃分析数据表明,其患病率约为30%,个别研究报告肥胖和/或代谢综合征患者的患病率甚至更高。与此同时,PDAC的发病率正在上升,预计很快将成为癌症相关死亡的第二大原因。鉴于早期PDAC检测和干预对提高生存率的重要性,探讨胰腺脂肪变性与PDAC之间的关系尤为及时。本综述旨在全面概述胰腺脂肪变性与PDAC之间的发病机制和临床关联,并讨论当前PDAC监测实践背景下的未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pancreatic Steatosis as a Risk Factor for Pancreatic Ductal Adenocarcinoma: Pathogenesis and Clinical Implications.

Pancreatic steatosis is defined as the ectopic accumulation of fat in the pancreas. While historically considered a benign incidental imaging finding, it is now recognized as a significant and potentially reversible risk factor for pancreatic ductal adenocarcinoma (PDAC) independent of obesity. Although its epidemiology is not well characterized, meta-analysis data suggest an approximately 30% prevalence, with individual studies reporting even higher rates among patients with obesity and/or metabolic syndrome. Concurrently, PDAC incidence is rising and is projected to soon become the second leading cause of cancer-related deaths. Given the critical importance of early PDAC detection and intervention for improving survival, it is particularly timely to explore the associations between pancreatic steatosis and PDAC. This review aims to provide a comprehensive overview of the pathogenesis and clinical associations between pancreatic steatosis and PDAC and to discuss future perspectives within the context of current PDAC surveillance practices.

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来源期刊
Clinical and Translational Gastroenterology
Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.00
自引率
0.00%
发文量
114
审稿时长
16 weeks
期刊介绍: Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.
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