细胞分裂素：从工作台到床边都可应用的强效真菌天然产品。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-03-03 DOI:10.1039/d4np00076e

Mohamed A. Tammam , Florbela Pereira , Elizabeth Skellam , Stefan Bidula , A. Ganesan , Amr El-Demerdash

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引用次数: 0

摘要

细胞chalasans是一类令人着迷的天然产物，具有复杂的化学结构和多种生物活性。它们以其复杂的化学结构而闻名，通常从各种真菌中分离出来。这些化合物由于其潜在的药理特性，包括抗菌、抗病毒和抗癌作用而引起了人们的关注。几十年来，研究人员一直在研究这些分子，以更好地了解它们的作用机制，并探索它们在医学和其他领域的潜在应用。本文综述了2000-2023年间424种真菌来源的细胞chalasans的结构多样性、生物合成来源、药代动力学及其在药物发现和开发中的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The cytochalasans: potent fungal natural products with application from bench to bedside†

Covering: 2000–2023

Cytochalasans are a fascinating class of natural products that possess an intricate chemical structure with a diverse range of biological activities. They are known for their complex chemical architectures and are often isolated from various fungi. These compounds have attracted attention due to their potential pharmacological properties, including antimicrobial, antiviral, and anticancer effects. For decades, researchers have studied these molecules to better understand their mechanisms of action and to explore their potential applications in medicine and other fields. This review article aims to shed light over the period 2000–2023 on the structural diversities of fungal derived cytochalasans, insights into their biosynthetic origins, pharmacokinetics and their promising therapeutic potential in drug discovery and development.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.