血浆蛋白质组学分析预测个体未来骨关节炎风险

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-02-24 DOI:10.1002/art.43143

Zijian Kang, Jianzheng Zhang, Wenxin Liu, Chen Zhu, Ying Zhu, Ping Li, Kai Li, Qiang Tong, Sheng-Ming Dai

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引用次数: 0

摘要

骨关节炎（OA）是一种广泛的退行性关节疾病，造成相当大的社会经济负担。尽管在遗传和环境方面取得了进展，但早期诊断仍然受到早期阶段缺乏明显症状和准确生物标志物的限制。本研究旨在确定与OA未来风险相关的血浆蛋白，并建立预测模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Plasma proteomic profiles predict individual future osteoarthritis risk

Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during the initial phases and accurate biomarkers. This study aims to identify plasma proteins associated with future risk of OA and develop a predictive model.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.