中性粒细胞可能与2型糖尿病患者的肠道损伤和视网膜病变有关

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Senegal Carty
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引用次数: 0

摘要

2型糖尿病(T2DM)与视网膜病变相关,可导致视力丧失。一项新的研究表明,由中性粒细胞胞外陷阱(NETs)引起的肠道内膜损伤可能会通过将肠道抗原释放到血液中并引起全身炎症,从而促进2型糖尿病患者的视网膜病变。研究人员随后研究了抑制NETosis (NET释放)是否可以减少db/db小鼠的肠道损伤和视网膜损伤,db/db小鼠通过基因工程治疗为2型糖尿病。研究小组从药理学上抑制了一组小鼠的NETosis,并给另一组小鼠单独注射生理盐水作为对照。接下来,科学家们通过灌胃给小鼠注射荧光葡聚糖,然后测量有多少葡聚糖从小肠渗漏到血浆中。接受NETosis抑制剂的转基因小鼠的肠通透性明显低于对照小鼠。与对照组相比,接受抑制剂治疗的小鼠的视网膜损伤也略少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Neutrophils might link intestinal damage to retinopathy in type 2 diabetes mellitus

Neutrophils might link intestinal damage to retinopathy in type 2 diabetes mellitus
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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