前驱：孤立的快速眼动睡眠行为障碍的现行标准。

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-02-22 DOI:10.1002/mdc3.70006

Anja Ophey, Sinah Röttgen, Julia Reichrath, Elke Kalbe, Gereon R Fink, Michael Sommerauer

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引用次数: 0

摘要

背景：孤立的快速眼动睡眠行为障碍（iRBD）表明早期α-突触核蛋白病变，约90%的个体表型转化为帕金森病（PD）、路易体痴呆（DLB）或多系统萎缩（MSA）。最近，前驱疾病的定义（pPD, pDLB, pMSA）被介绍。目的：在已建立的iRBD队列中调查前驱症状定义的重叠。方法：我们将pPD、pDLB和pMSA的现行诊断标准应用于来自当地iRBD队列的N = 55个人。结果：除两名患者外，所有患者均满足至少一种前驱疾病定义；大多数个体被归类为pPD（94.5%）。56%的个体满足一个以上的定义：32.7%的pMSA&pPD， 10.9%的pDLB&pPD， 12.7%的三者都满足（pPD&pDLB&pMSA）。认知筛查[(pPD = pMSA) > pDLB]，运动症状[pPD]结论：观察到的重叠导致患者咨询和风险披露的挑战。更好的鉴别有助于α-突触核蛋白病早期阶段的研究。

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Being Prodromal: Current Criteria in the Context of Isolated REM Sleep Behavior Disorder.

Background: Isolated REM sleep behavior disorder (iRBD) indicates an early α-synucleinopathy with approximately 90% of individuals pheno-converting to Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal disease definitions (pPD, pDLB, pMSA) have been introduced.

Objective: To investigate the overlap of prodromal definitions in an established iRBD cohort.

Methods: We applied the current diagnostic criteria for pPD, pDLB, and pMSA to N = 55 individuals from the local iRBD cohort.

Results: All except two individuals fulfilled at least one of the prodromal disease definitions; most individuals were classified as pPD (94.5%). 56% of the individuals fulfilled more than one definition: 32.7% pMSA&pPD, 10.9% pDLB&pPD, and 12.7% all three (pPD&pDLB&pMSA). The cognitive screening [(pPD = pMSA) > pDLB], motor symptoms [pPD < (pDLB = pMSA)], and olfactory testing [(pPD = pDLB) < pMSA] significantly differed between groups.

Conclusions: The observed overlap leads to challenges in patient counseling and risk disclosure. Better discrimination will facilitate research in early α-synucleinopathy phases.

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)