内生真菌annlohypoxylon stygium A888的两个新四克隆体。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI:10.1080/10286020.2025.2464683

Zhi-Shen Shao , Yu-Chan Chen , Wei-Peng Ma , Sai-Ni Li , Hong-Xin Liu , Wei-Min Zhang , Xiao-Ying Chen

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引用次数: 0

摘要

从药用植物沉香（Aquilaria sinensis）内生真菌annlohypoxylon stygium A888的固体发酵乙酸乙酯萃取物中分离得到两个新的四氯酮类化合物Annulohypoxylon hyporins A(1)和B(2)，以及13个已知化合物（3 ~ 15）。通过紫外-可见光谱（UV）、红外光谱（IR）、质谱（MS）、电子圆二色性（ECD）计算和核磁共振（NMR）等详细分析，确定了环低孔蛋白A和B的结构。生物活性测定表明，化合物3和4具有显著的α-葡萄糖苷酶抑制活性，IC50值分别为64.00和32.90µM。

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Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888

Two new tetralones, annulohyporins A (1) and B (2), along with thirteen known compounds (3–15), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus Annulohypoxylon stygium A888, which was isolated from the medicinal plant Aquilaria sinensis. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds 3 and 4 had significant α-glucosidase inhibitory activities with IC₅₀ values of 64.00 and 32.90 µM, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.