Alejandro Llamedo, Pablo Rodríguez, Carolina de Passos, Sandra Freitas-Rodriguez, Ana M Coto, Raquel G Soengas, Rebeca Alonso-Bartolomé
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引用次数: 0
摘要
本研究描述了一种含有维生素c衍生物3- o -乙基-l -抗坏血酸（EAA）的新型脂质体配方的开发。EAA负载的脂质体具有完整的表征，粒径和zeta电位值适合于给药。皮肤渗透研究表明，与游离EAA相比，脂质体制剂增强了EAA在皮肤中的保留率。此外，研究了EAA脂质体局部处理对皮肤外植体光老化标志物的影响。EAA脂质体对细胞代谢具有保护或刺激作用。最后，脂质体EAA对炎症标志物有显著影响，减少与紫外线引起的皮肤损伤相关的细胞外基质降解。这些发现为开发先进化妆品的脂质体制剂的潜力提供了有价值的见解。
Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability.
This study describes the development of a novel liposomal formulation incorporating 3-O-ethyl-L-ascorbic acid (EAA), a derivative of vitamin C. The EAA-loaded liposomes were fully characterized, particle size and zeta potential values suitable for drug delivery. The skin penetration studies revealed that liposomal formulation enhanced EAA retention in the skin compared to free EAA. Additionally, the impact of topical treatments with liposomal EAA on photo-aging markers in skin explants was investigated. EAA charged liposomes display a protective or stimulatory effect on cellular metabolism. Finally, liposomal EAA have a significant effect on the inflamatory markers, reducing the extracellular matrix degradation associated with UV-induced damage of skin. These findings provide valuable insights into the potential of liposomal formulations for the development of advanced cosmetic products.
期刊介绍：
The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society.
The scope of the Journal includes:
Formulation and characterisation of systems
Formulation engineering of systems
Synthetic and physical lipid chemistry
Lipid Biology
Biomembranes
Vaccines
Emerging technologies and systems related to liposomes and vesicle type systems
Developmental methodologies and new analytical techniques pertaining to the general area
Pharmacokinetics, pharmacodynamics and biodistribution of systems
Clinical applications.
The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.
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