化脓性汗腺炎患者发生斑秃的风险增加：美国一项多中心队列研究

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2025-02-20 DOI:10.1016/j.bj.2025.100837

Shuo-Yan Gau, Chih-Wei Chen, Yu-Hsun Wang, Ching-Chi Chi, James Cheng-Chung Wei

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引用次数: 0

摘要

背景：化脓性汗腺炎（HS）和斑秃（AA）具有相似的炎症途径和促炎细胞因子。然而，HS与AA之间的关系尚不清楚。我们的目的是评估HS患者发生AA的风险。材料和方法：我们利用TriNetX研究网络中的美国合作网络进行了一项多中心队列研究。招募HS诊断的患者，采用1:1倾向评分匹配确定非HS对照组。在随访期间计算不同敏感性模型AA的风险比（HR）。结果：与非HS对照组相比，HS患者在15年随访期间发生AA的风险高1.79倍（95%可信区间（CI） 1.31-2.44）。在3年和8年的随访中也观察到类似的趋势。女性HS患者发生AA的风险是非HS女性患者的1.75倍（95% CI 1.23-2.48）。然而，在男性HS患者中没有观察到这种趋势(HR 1.52；95% ci 0.79-2.94)。结论：HS患者与AA事件风险增加相关。临床医生应该意识到所观察到的关联，并在未来的实验室研究中澄清这两种疾病之间的实际免疫学相互作用。

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Increased risk of incident alopecia areata among patients with hidradenitis suppurativa: A multicenter cohort study in the United States.

Background: Hidradenitis suppurativa (HS) and alopecia areata (AA) share similar inflammatory pathway and pro-inflammatory cytokines. However, the association between HS and AA was unclear. We aimed to evaluate the risk of incident AA among patients with HS.

Material and methods: We performed a multicenter cohort study by using the US Collaborative Network in the TriNetX Research Network. Patients with HS diagnosis were recruited and 1:1 propensity score matching was performed to identify the non-HS control group. Hazard ratio (HR) of AA in different sensitivity models were calculated within the follow-up periods.

Results: Comparing with non-HS controls, the risk of incident AA in HS patients was 1.79-fold higher (95% confidence interval (CI) 1.31-2.44) within 15-year follow up. Similar trends were observed in 3-year and 8-year follow up. For female HS patients, the risk of incident AA was 1.75-fold higher than non-HS female (95% CI 1.23-2.48). However, the trend was not observed in male HS patients (HR 1.52; 95% CI 0.79-2.94).

Conclusions: Patients with HS were associated with increased risk of incident AA. Clinicians should be aware of the observed association and the actual immunological interplay between the two diseases should be clarified in future lab-based studies.

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.