工作场所药物检测——阳性检测结果的流行、最常见的物质和医学审查的重要性。

IF 2.6 3区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Anders Helander, Fredrik Sparring
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引用次数: 0

摘要

最近的数据表明,在工作生活中,受管制物质的使用正在增加,这可能对工作环境、性能和安全产生负面影响。许多雇主都有酒精和毒品政策,其中描述了预防措施和早期发现非法药物使用的常规措施。这通常包括提供有关最近使用情况的客观信息的药物测试,可以常规、随机和怀疑地进行。然而,对于某些物质,药物测试阳性也可能是由于处方药。滥用和处方的受控物质包括安非他明(ADHD药物)、苯二氮卓类药物和阿片类药物。在2023年对瑞典工作场所23,900例尿液和口服液药物检测结果进行的一项研究中,4.6%的人对一种或多种受控物质检测呈阳性。大多数样本是在随机检测(40%)和新就业(36%)中收集的,而在与事故或事件有关或涉嫌吸毒的案件中观察到的药物阳性样本比例最高。随机药物检测呈阳性的比例最高的是建筑业。最常见的药物是大麻(占40%),安非他明(占20%),可卡因和苯二氮卓类药物(各占10%)。然而,许多含有阿片类药物(71%)、安非他明(63%)和苯二氮卓类药物(44%)的样品经经过专业培训的医疗审查干事核实为医疗处方所致,而含有大麻或可卡因的样品几乎完全是由于非法使用药物所致。考虑到药检阳性对工作寿命的潜在负面影响,MRO应在结果成为最终结果之前对其进行验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Workplace Drug Testing-Prevalence of Positive Test Results, Most Common Substances, and Importance of Medical Review.

Recent data indicate that the use of controlled substances is increasing in working life, which can negatively affect work environment, performance, and safety. Many employers have an alcohol and drug policy that describes routines for preventive measures and early detection of illicit drug use. This often includes drug tests that provide objective information about recent use, and can be done routinely, randomly, and on suspicion. For some substances, however, a positive drug test may also result from prescription as medicine. Controlled substances that are abused and prescribed include amphetamines (ADHD medication), benzodiazepines and opiates. In a 2023 study of 23,900 urine and oral fluid drug test results from Swedish workplaces, 4.6% tested positive for one or more controlled substances. Most samples were collected in connection with random testing (40%) and new employment (36%), whereas the highest proportions of drug-positive samples were observed in cases related to accidents or incidents, or on suspicion of drug use. The highest percentage of positive random drug tests was recorded in the construction sector. The most common substances were cannabis (> 40% of cases), amphetamine (> 20%), and cocaine and benzodiazepines (> 10% each). However, many samples containing opiates (71% of cases), amphetamine (63%) and benzodiazepines (44%) were verified by a specialist trained Medical Review Officer (MRO) to be due to medical prescription, while those containing cannabis or cocaine were almost entirely due to illicit drug use. Considering the potentially negative consequences of a positive drug test in working life, an MRO should verify the results before they become final.

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来源期刊
Drug Testing and Analysis
Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL
CiteScore
5.90
自引率
24.10%
发文量
191
审稿时长
2.3 months
期刊介绍: As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.
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