IF 1.9
3区 化学
Q3 CHEMISTRY, APPLIED
引用次数: 0
摘要
利用硅胶、Sephadex LH-20 柱色谱法和制备型高效液相色谱法（HPLC），从 Chaetomium elatum 分离出两种未曾描述过的苯并呋喃衍生物（1-2）。化合物 1-2 的结构由 HRESIMS、NMR、HMBC、NOESY 光谱分析和 ECD 计算表征。化合物 1-2 能够减轻脂多糖（LPS）在 RAW264.7 巨噬细胞中引发的炎症反应，RT-PCR 检测结果表明，当浓度为 30 μM 时，关键炎症因子受到抑制。这些发现表明，1-2 具有良好的抗炎特性。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Two undescribed benzofuran derivatives from chaetomium elatum.
Two undescribed benzofuran derivatives (1-2) were isolated from Chaetomium elatum using silica gel, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (HPLC). The structures of compound 1-2 were characterised by HRESIMS, NMR, HMBC, NOESY spectral analyses, and ECD calculations. Compounds 1-2 demonstrated the ability to mitigate the inflammatory response triggered by lipopolysaccharide (LPS) in RAW264.7 macrophages, as evidenced by RT-PCR assay results showing suppression of key inflammatory factors at the concentration of 30 μM. These findings suggest that 1-2 possess promising anti-inflammatory properties.
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来源期刊
Natural Product Research
化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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