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IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-02-24 DOI:10.1002/advs.202570051

Dongkwan Shin, Jeong-Ryeol Gong, Seoyoon D. Jeong, Youngwon Cho, Hwang-Phill Kim, Tae-You Kim, Kwang-Hyun Cho

引用次数: 0

摘要

肿瘤发生的逆转细胞命运可以通过高维空间中的吸引子景观进行定量评估，该景观受底层基因调控网络错综复杂的相互作用的支配。在编号为 2412503 的文章中，Kwang-Hyun Cho 及其合作者提出了一个系统框架 REVERT，该框架旨在确定结直肠肿瘤发生转变过程中的逆转开关，从而操纵吸引子景观，将癌细胞逆转为正常细胞状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis (Adv. Sci. 8/2025)

查看原文本刊更多论文

Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis (Adv. Sci. 8/2025)

Reversion of Tumorigenesis

A cell fate can be quantitatively evaluated through an attractor landscape in a high-dimensional space, governed by intricate interactions of the underlying gene regulatory network. In article number 2412503, Kwang-Hyun Cho and co-workers present a systems framework, REVERT developed to identify a reversion switch in the transition of colorectal tumorigenesis, enabling the manipulation of the attractor landscape to revert cancer cells into normal cell states.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.