木糖醇和氟化物清漆对正畸患者生物膜和唾液的影响:一项三盲随机临床试验

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Neda Babanouri, Sarina Sahmeddini, Setayesh Khadang, Abdollah Bazargani
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引用次数: 0

摘要

目的固定正畸器与较高水平的牙菌斑和唾液细菌有关,这是导致龋齿的原因。木糖醇和氟化物联合使用,两者都用于预防龋齿,其效果尚不确定。因此,本研究评估了氟化物和木糖醇清漆对唾液细菌和正畸托槽周围生物膜的综合影响。材料与方法采用单中心、四臂、平行组、三盲、随机临床试验。共纳入120例需要固定正畸治疗的患者。患者被随机分为以下四组:氟化物组、木糖醇组、氟化物和木糖醇联合组和对照组。生物膜和唾液取样在两个间隔进行:T0(第一次支架粘接,涂清漆前)和T1(涂清漆后6周)。用CFU法计数变形链球菌和乳酸菌的数量。结果氟化物及氟化物/木糖醇联合清漆可显著降低唾液和生物膜中变形链球菌和乳酸菌的相对数量(p < 0.05),且效果优于木糖醇清漆。氟化物和氟化物/木糖醇复合清漆对唾液和牙齿生物膜中变形链球菌和乳酸杆菌菌落的变化无显著差异。此外,木糖醇与其他两种活性清漆在生物膜变形链球菌和乳酸菌的减少方面没有显著差异。结论氟化物和氟化物/木糖醇复合清漆对口腔唾液和口腔生物膜细菌的影响无显著差异,其效果优于木糖醇清漆。伊朗临床试验注册中心标识符:IRCT20181121041713N4;https://fa.irct.ir/trial/58543
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Xylitol and Fluoride Varnish on Biofilm and Saliva in Orthodontic Patients: A Triple-Blind Randomized Clinical Trial

Effect of Xylitol and Fluoride Varnish on Biofilm and Saliva in Orthodontic Patients: A Triple-Blind Randomized Clinical Trial

Objectives

Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects of combining xylitol and fluoride, both used in caries prevention, are uncertain. Thus, this study assessed the combined impact of fluoride and xylitol varnish on bacteria in saliva and biofilms around orthodontic brackets.

Materials and Methods

A single-center, four-arm, parallel-group, triple-blind, randomized clinical trial was conducted. A total of 120 patients who required fixed orthodontic treatment were included. Patients were sorted into one of the following groups at random: fluoride, xylitol, combined fluoride and xylitol, and control. Biofilm and saliva sampling was performed at two intervals: T0 (first session of bracket bonding, before application of the varnish) and T1 (6 weeks after application of the varnish). The number of Streptococcus mutans and Lactobacillus was counted using the CFU method.

Results

The relative number of S. mutans and lactobacilli in saliva and biofilm significantly decreased following the application of fluoride and combined fluoride/xylitol varnish (p < 0.05) and were more effective than xylitol varnish. There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in S. mutans and Lactobacillus colonies in saliva and dental biofilms. Additionally, there was no significant difference between xylitol and the two other active varnishes regarding reduction in biofilm S. mutans and Lactobacillus.

Conclusion

There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in the studied bacteria in saliva and dental biofilms, and they were more effective than xylitol varnish.

Trial Registration

The Iranian Registry of Clinical Trial identifier: IRCT20181121041713N4; https://fa.irct.ir/trial/58543

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来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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