{"title":"木糖醇和氟化物清漆对正畸患者生物膜和唾液的影响：一项三盲随机临床试验","authors":"Neda Babanouri, Sarina Sahmeddini, Setayesh Khadang, Abdollah Bazargani","doi":"10.1002/cre2.70062","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects of combining xylitol and fluoride, both used in caries prevention, are uncertain. Thus, this study assessed the combined impact of fluoride and xylitol varnish on bacteria in saliva and biofilms around orthodontic brackets.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>A single-center, four-arm, parallel-group, triple-blind, randomized clinical trial was conducted. A total of 120 patients who required fixed orthodontic treatment were included. Patients were sorted into one of the following groups at random: fluoride, xylitol, combined fluoride and xylitol, and control. Biofilm and saliva sampling was performed at two intervals: T0 (first session of bracket bonding, before application of the varnish) and T1 (6 weeks after application of the varnish). The number of <i>Streptococcus mutans</i> and <i>Lactobacillus</i> was counted using the CFU method.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The relative number of <i>S. mutans</i> and <i>lactobacilli</i> in saliva and biofilm significantly decreased following the application of fluoride and combined fluoride/xylitol varnish (<i>p</i> < 0.05) and were more effective than xylitol varnish. There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in <i>S. mutans</i> and <i>Lactobacillus</i> colonies in saliva and dental biofilms. Additionally, there was no significant difference between xylitol and the two other active varnishes regarding reduction in biofilm <i>S. mutans</i> and <i>Lactobacillus</i>.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in the studied bacteria in saliva and dental biofilms, and they were more effective than xylitol varnish.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>The Iranian Registry of Clinical Trial identifier: IRCT20181121041713N4; https://fa.irct.ir/trial/58543</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70062","citationCount":"0","resultStr":"{\"title\":\"Effect of Xylitol and Fluoride Varnish on Biofilm and Saliva in Orthodontic Patients: A Triple-Blind Randomized Clinical Trial\",\"authors\":\"Neda Babanouri, Sarina Sahmeddini, Setayesh Khadang, Abdollah Bazargani\",\"doi\":\"10.1002/cre2.70062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects of combining xylitol and fluoride, both used in caries prevention, are uncertain. Thus, this study assessed the combined impact of fluoride and xylitol varnish on bacteria in saliva and biofilms around orthodontic brackets.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>A single-center, four-arm, parallel-group, triple-blind, randomized clinical trial was conducted. A total of 120 patients who required fixed orthodontic treatment were included. Patients were sorted into one of the following groups at random: fluoride, xylitol, combined fluoride and xylitol, and control. Biofilm and saliva sampling was performed at two intervals: T0 (first session of bracket bonding, before application of the varnish) and T1 (6 weeks after application of the varnish). The number of <i>Streptococcus mutans</i> and <i>Lactobacillus</i> was counted using the CFU method.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The relative number of <i>S. mutans</i> and <i>lactobacilli</i> in saliva and biofilm significantly decreased following the application of fluoride and combined fluoride/xylitol varnish (<i>p</i> < 0.05) and were more effective than xylitol varnish. There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in <i>S. mutans</i> and <i>Lactobacillus</i> colonies in saliva and dental biofilms. Additionally, there was no significant difference between xylitol and the two other active varnishes regarding reduction in biofilm <i>S. mutans</i> and <i>Lactobacillus</i>.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in the studied bacteria in saliva and dental biofilms, and they were more effective than xylitol varnish.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Trial Registration</h3>\\n \\n <p>The Iranian Registry of Clinical Trial identifier: IRCT20181121041713N4; https://fa.irct.ir/trial/58543</p>\\n </section>\\n </div>\",\"PeriodicalId\":10203,\"journal\":{\"name\":\"Clinical and Experimental Dental Research\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-02-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70062\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Dental Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Effect of Xylitol and Fluoride Varnish on Biofilm and Saliva in Orthodontic Patients: A Triple-Blind Randomized Clinical Trial
Objectives
Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects of combining xylitol and fluoride, both used in caries prevention, are uncertain. Thus, this study assessed the combined impact of fluoride and xylitol varnish on bacteria in saliva and biofilms around orthodontic brackets.
Materials and Methods
A single-center, four-arm, parallel-group, triple-blind, randomized clinical trial was conducted. A total of 120 patients who required fixed orthodontic treatment were included. Patients were sorted into one of the following groups at random: fluoride, xylitol, combined fluoride and xylitol, and control. Biofilm and saliva sampling was performed at two intervals: T0 (first session of bracket bonding, before application of the varnish) and T1 (6 weeks after application of the varnish). The number of Streptococcus mutans and Lactobacillus was counted using the CFU method.
Results
The relative number of S. mutans and lactobacilli in saliva and biofilm significantly decreased following the application of fluoride and combined fluoride/xylitol varnish (p < 0.05) and were more effective than xylitol varnish. There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in S. mutans and Lactobacillus colonies in saliva and dental biofilms. Additionally, there was no significant difference between xylitol and the two other active varnishes regarding reduction in biofilm S. mutans and Lactobacillus.
Conclusion
There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in the studied bacteria in saliva and dental biofilms, and they were more effective than xylitol varnish.
Trial Registration
The Iranian Registry of Clinical Trial identifier: IRCT20181121041713N4; https://fa.irct.ir/trial/58543
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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