Xiao-Yan Duan, Dong-Bao Hu, Hataichanok Pandith, Terd Disayathanoowat, Xue Bai, Jun Yang, Ji-Feng Luo, Angkhana Inta, Yue-Hu Wang
{"title":"沉香非树脂心材的化学成分及抗菌性能研究","authors":"Xiao-Yan Duan, Dong-Bao Hu, Hataichanok Pandith, Terd Disayathanoowat, Xue Bai, Jun Yang, Ji-Feng Luo, Angkhana Inta, Yue-Hu Wang","doi":"10.1007/s10600-025-04571-z","DOIUrl":null,"url":null,"abstract":"<p>Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (<i>R</i>)-2-(1-hydroxy-2- phenylethyl)chromone (<b>1</b>), and one new resorcylic acid lactone, (<i>S</i>)-de-O-methylhispidulactone A (<b>2</b>), were isolated from the nonresinous heartwood of <i>Aqualaria sinensis</i> (Lour.) Spreng. Among these compounds, (<i>S</i>)-de-<i>O</i>-methylhispidulactone A (<b>2</b>), 2-(2-phenylethyl)chromone (<b>4</b>), 2-[2-(4-hydroxyphenyl)ethyl]chromone (<b>7</b>), 6-methoxy-2-(2-phenylethyl)chromone (<b>8</b>), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (<b>9</b>), 2-[2-(3-methoxyphenyl)ethyl]chromone (<b>10</b>), 6,7-dimethoxy-2-(2-phenylethyl)chromone (<b>11</b>), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (<b>13</b>), (+)-(<i>R</i>)-de-<i>O</i>-methyllasiodiplodin (<b>14</b>), lasiodiplodin (<b>15</b>), and (3<i>R</i>)-(–)-melliein (<b>20</b>) exhibited antifungal activity against <i>Epidermophyton floccosum</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum gypseum</i>, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (<i>R</i>)-2-(2-hydroxy-2-phenylethyl)chromone (<b>3b</b>), <b>7</b>, <b>8</b>, <b>9</b>, <b>14, 15</b>, 5-hydroxy-7,3′,4′- trimethoxyflavone (<b>17</b>), and velutin (<b>18</b>) demonstrated antibacterial effects against <i>Staphylococcus aureus</i>, with MIC values ranging from 20.2 to 96.0 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"42 - 51"},"PeriodicalIF":0.8000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chemical Constituents and Antimicrobial Properties of the Nonresinous Heartwood of Aquilaria sinensis\",\"authors\":\"Xiao-Yan Duan, Dong-Bao Hu, Hataichanok Pandith, Terd Disayathanoowat, Xue Bai, Jun Yang, Ji-Feng Luo, Angkhana Inta, Yue-Hu Wang\",\"doi\":\"10.1007/s10600-025-04571-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (<i>R</i>)-2-(1-hydroxy-2- phenylethyl)chromone (<b>1</b>), and one new resorcylic acid lactone, (<i>S</i>)-de-O-methylhispidulactone A (<b>2</b>), were isolated from the nonresinous heartwood of <i>Aqualaria sinensis</i> (Lour.) Spreng. Among these compounds, (<i>S</i>)-de-<i>O</i>-methylhispidulactone A (<b>2</b>), 2-(2-phenylethyl)chromone (<b>4</b>), 2-[2-(4-hydroxyphenyl)ethyl]chromone (<b>7</b>), 6-methoxy-2-(2-phenylethyl)chromone (<b>8</b>), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (<b>9</b>), 2-[2-(3-methoxyphenyl)ethyl]chromone (<b>10</b>), 6,7-dimethoxy-2-(2-phenylethyl)chromone (<b>11</b>), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (<b>13</b>), (+)-(<i>R</i>)-de-<i>O</i>-methyllasiodiplodin (<b>14</b>), lasiodiplodin (<b>15</b>), and (3<i>R</i>)-(–)-melliein (<b>20</b>) exhibited antifungal activity against <i>Epidermophyton floccosum</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum gypseum</i>, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (<i>R</i>)-2-(2-hydroxy-2-phenylethyl)chromone (<b>3b</b>), <b>7</b>, <b>8</b>, <b>9</b>, <b>14, 15</b>, 5-hydroxy-7,3′,4′- trimethoxyflavone (<b>17</b>), and velutin (<b>18</b>) demonstrated antibacterial effects against <i>Staphylococcus aureus</i>, with MIC values ranging from 20.2 to 96.0 μM.</p>\",\"PeriodicalId\":514,\"journal\":{\"name\":\"Chemistry of Natural Compounds\",\"volume\":\"61 1\",\"pages\":\"42 - 51\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry of Natural Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10600-025-04571-z\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04571-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Chemical Constituents and Antimicrobial Properties of the Nonresinous Heartwood of Aquilaria sinensis
Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (R)-2-(1-hydroxy-2- phenylethyl)chromone (1), and one new resorcylic acid lactone, (S)-de-O-methylhispidulactone A (2), were isolated from the nonresinous heartwood of Aqualaria sinensis (Lour.) Spreng. Among these compounds, (S)-de-O-methylhispidulactone A (2), 2-(2-phenylethyl)chromone (4), 2-[2-(4-hydroxyphenyl)ethyl]chromone (7), 6-methoxy-2-(2-phenylethyl)chromone (8), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (9), 2-[2-(3-methoxyphenyl)ethyl]chromone (10), 6,7-dimethoxy-2-(2-phenylethyl)chromone (11), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (13), (+)-(R)-de-O-methyllasiodiplodin (14), lasiodiplodin (15), and (3R)-(–)-melliein (20) exhibited antifungal activity against Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (R)-2-(2-hydroxy-2-phenylethyl)chromone (3b), 7, 8, 9, 14, 15, 5-hydroxy-7,3′,4′- trimethoxyflavone (17), and velutin (18) demonstrated antibacterial effects against Staphylococcus aureus, with MIC values ranging from 20.2 to 96.0 μM.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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