丙酮酸甲酯吡啶-3-基甲基亚基衍生物的合成、与Pd（II）的络合及细胞毒性研究

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-02-04 DOI:10.1007/s10600-025-04584-8

M. S. Denisov, A. O. Voronina, O. A. Maiorova

引用次数: 0

摘要

合成了吡啶-3-基甲基乙基二烯甲酯衍生物。得到了6个新的Pd（II）配合物。MTT法评估了这些化合物对A549（非小细胞肺癌）和HCT116细胞系（结肠癌）的影响。3-{(E)-[28-甲氧基-3,28-二恶唑-20(29)-烯-2-乙基]甲基}-1-甲基吡啶四氟硼酸盐对HCT116细胞株具有较强的细胞毒活性（IC50 = 7.21 μM）。

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Synthesis, Complexation with Pd(II), and Cytotoxicity of Pyridin-3-Ylmethylylidene Derivatives of Methyl Betulonate

Pyridin-3-ylmethylylidene derivatives of methyl betulonate were synthesized. Six new Pd(II) complexes of them were obtained. The effects of these compounds on A549 (non-small-cell lung carcinoma) and HCT116 cell lines (colon cancer) were assessed by the MTT assay. 3-{(E)-[28-Methoxy-3,28-dioxolup-20(29)-en-2-ylidene]methyl}-1-methylpyridinium tetrafluoroborate exhibited potent cytotoxic activity on HCT116 cell line (IC₅₀ = 7.21 μM).

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.