1,2,3-三唑连接的（C-30）取代狼烷三萜和没食子酸衍生物的合成及其生物活性

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-02-04 DOI:10.1007/s10600-025-04583-9

S. A. Popov, Z. Qi, G. Yang, C. Wang, M. D. Semenova, A. V. Shpatov, E. E. Shults

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引用次数: 0

摘要

通过铜催化的[3β，28-二乙酰氧基-20(29)-lupen-30-酰基]叠氮化物和3β-乙酰氧基-20(29)-en-30-叠氮-28-酸与不同位置具有异丙基取代基的没食子酸衍生物的环加成反应，制备了通过1,2,3-三唑连接剂与没食子酸衍生物结合的新的狼烷三萜缀合物。基于白桦林的偶联物4与含有二恶烷基团的改性没食子酸酯取代基具有有效的抗氧化特性和抗炎活性（抑制NO高表达）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Biological Activity of Derivatives of (C-30)-Substituted Lupane Triterpenoids and Gallic Acid Bound Through a 1,2,3-Triazole Linker

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Synthesis and Biological Activity of Derivatives of (C-30)-Substituted Lupane Triterpenoids and Gallic Acid Bound Through a 1,2,3-Triazole Linker

New conjugates of lupane triterpenoids bound through a 1,2,3-triazole linker with gallate derivatives were prepared via Cu-catalyzed cycloaddition reactions of [3β,28-diacetoxy-20(29)-lupen-30-yl]azide and 3β-acetoxylup-20(29)-en-30-azido-28-oic acid with gallate derivatives with propargyl substituents in various positions. Conjugate 4 based on betulin with a modified gallate substituent containing a dioxolane moiety possessed potent antioxidant properties and anti-inflammatory activity (suppression of NO hyperexpression).

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.