瑞典血栓易发谱系的后代患精神疾病的风险：一项全国性的家庭研究

IF 3.4 3区医学 Q2 HEMATOLOGY

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-01-01 DOI:10.1016/j.rpth.2025.102692

Bengt Zöller, Jan Sundquist, Kristina Sundquist, Henrik Ohlsson

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引用次数: 0

摘要

精神疾病与静脉血栓栓塞（VTE）有关。然而，据我们所知，还没有全国性的研究调查静脉血栓栓塞和精神疾病之间的家族关系。目的：我们采用基于家系的方法，根据家系中静脉血栓栓塞的密度，检查扩展家系后代患精神疾病的风险。方法采用瑞典全国家庭研究。我们从瑞典多代登记中确定了总共482,184个瑞典血统，平均包含14.2个父母，阿姨/叔叔，祖父母和核心全兄弟姐妹的堂兄弟姐妹，我们称之为谱系后代（n = 751,060）。然后，我们根据静脉血栓栓塞病例的密度推导出8个经验类。后代患精神疾病的风险由谱系中静脉血栓密度的函数决定。静脉血栓栓塞和精神障碍（F00-F69）的诊断是根据瑞典登记册中的国际疾病分类代码确定的。所有结果均经Bonferroni校正。结果较高的静脉血栓栓塞（VTE）密度与后代患精神疾病的风险有显著但微弱的相关性，尤其是谱系中的女性。此外，家系VTE密度在后代中与药物滥用障碍、情绪（情感）障碍、神经症、压力相关和躯体形式障碍、与心理障碍和身体因素相关的行为综合征、成人人格和行为的人格障碍、抑郁症和焦虑症显著相关。结论VTE密度高的家系后代，尤其是女性，在一些精神障碍方面有轻微的劣势。静脉血栓栓塞与几种精神疾病具有家族易感性，尽管较弱。

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The risk for psychiatric disorders in offspring from thrombosis-prone pedigrees in Sweden: a nationwide family study

Background

Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders.

Objectives

We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees.

Methods

This was a Swedish national family study. We identified a total of 482,184 Swedish pedigrees from the Swedish Multigeneration Register containing a mean of 14.2 parents, aunts/uncles, grandparents, and cousins of a core full-sibship that we termed the pedigree offspring (n = 751,060). We then derived 8 empirical classes of these pedigrees based on the density of cases of VTE. The risk was determined in offspring for psychiatric disorders as a function of VTE density in their pedigrees. Diagnoses of VTE and psychiatric disorders (F00-F69) were determined according to the International Classification of Diseases codes in Swedish registers. All results were Bonferroni corrected.

Results

Higher VTE density, especially for females in pedigrees, was significantly but weakly associated in the offspring with a higher risk of psychiatric disorders. Moreover, VTE density in pedigrees was significantly associated in the offspring with substance abuse disorders, mood (affective) disorders, neurotic, stress-related, and somatoform disorders, behavioral syndromes associated with psychological disturbances and physical factors, personality disorders of adult personality and behavior, depression, and anxiety disorders.

Conclusion

Offspring of pedigrees with a high density of VTE, especially for females, are slightly disadvantaged regarding several psychiatric disorders. VTE shares familial susceptibility, albeit weak, with several psychiatric disorders.

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