K Taylor Wild, Holly L Hedrick, Natalie E Rintoul, Anne M Ades, Juliana S Gebb, Leny Mathew, Tom Reynolds, Anna Bostwick, Elizabeth Eppley, Sabrina Flohr, N Scott Adzick, Elizabeth E Foglia
{"title":"婴儿先天性膈疝的黄金时间管理：在一个大容量中心的15年经验。","authors":"K Taylor Wild, Holly L Hedrick, Natalie E Rintoul, Anne M Ades, Juliana S Gebb, Leny Mathew, Tom Reynolds, Anna Bostwick, Elizabeth Eppley, Sabrina Flohr, N Scott Adzick, Elizabeth E Foglia","doi":"10.1038/s41372-025-02226-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To review the evolution of golden hour management and outcomes for infants with congenital diaphragmatic hernia (CDH).</p><p><strong>Study design: </strong>Retrospective single center cohort study of infants with CDH born 2008-2023 at a quaternary children's hospital. Infants were grouped into 3 epochs: 2008-2013, 2014-2018, and 2019-2023. Outcome measures included extracorporeal membrane oxygenation therapy and survival.</p><p><strong>Result: </strong>There were 454 infants, including 106 (2008-2013), 156 (2014-2018), and 192 (2019-2023). Despite increased disease severity, survival improved over time, from 71% (2008-2013) to 82% (2014-2018) and 83% (2019-2023), p = 0.02 for trend, with no difference in ECMO utilization.</p><p><strong>Conclusion: </strong>Management of infants with CDH continues to evolve with ongoing experience at our high-volume center. Despite increasing severity of illness, survival outcomes have improved over time. In the absence of clinical trial data, observational data should be evaluated rigorously to inform care in a data-driven manner.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Golden hour management of infants with congenital diaphragmatic hernia: 15 year experience at a high-volume center.\",\"authors\":\"K Taylor Wild, Holly L Hedrick, Natalie E Rintoul, Anne M Ades, Juliana S Gebb, Leny Mathew, Tom Reynolds, Anna Bostwick, Elizabeth Eppley, Sabrina Flohr, N Scott Adzick, Elizabeth E Foglia\",\"doi\":\"10.1038/s41372-025-02226-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To review the evolution of golden hour management and outcomes for infants with congenital diaphragmatic hernia (CDH).</p><p><strong>Study design: </strong>Retrospective single center cohort study of infants with CDH born 2008-2023 at a quaternary children's hospital. Infants were grouped into 3 epochs: 2008-2013, 2014-2018, and 2019-2023. Outcome measures included extracorporeal membrane oxygenation therapy and survival.</p><p><strong>Result: </strong>There were 454 infants, including 106 (2008-2013), 156 (2014-2018), and 192 (2019-2023). Despite increased disease severity, survival improved over time, from 71% (2008-2013) to 82% (2014-2018) and 83% (2019-2023), p = 0.02 for trend, with no difference in ECMO utilization.</p><p><strong>Conclusion: </strong>Management of infants with CDH continues to evolve with ongoing experience at our high-volume center. Despite increasing severity of illness, survival outcomes have improved over time. In the absence of clinical trial data, observational data should be evaluated rigorously to inform care in a data-driven manner.</p>\",\"PeriodicalId\":16690,\"journal\":{\"name\":\"Journal of Perinatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41372-025-02226-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41372-025-02226-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Golden hour management of infants with congenital diaphragmatic hernia: 15 year experience at a high-volume center.
Objective: To review the evolution of golden hour management and outcomes for infants with congenital diaphragmatic hernia (CDH).
Study design: Retrospective single center cohort study of infants with CDH born 2008-2023 at a quaternary children's hospital. Infants were grouped into 3 epochs: 2008-2013, 2014-2018, and 2019-2023. Outcome measures included extracorporeal membrane oxygenation therapy and survival.
Result: There were 454 infants, including 106 (2008-2013), 156 (2014-2018), and 192 (2019-2023). Despite increased disease severity, survival improved over time, from 71% (2008-2013) to 82% (2014-2018) and 83% (2019-2023), p = 0.02 for trend, with no difference in ECMO utilization.
Conclusion: Management of infants with CDH continues to evolve with ongoing experience at our high-volume center. Despite increasing severity of illness, survival outcomes have improved over time. In the absence of clinical trial data, observational data should be evaluated rigorously to inform care in a data-driven manner.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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