{"title":"基于静息状态的功能磁共振成像揭示了脑功能网络与耳鸣风险的因果关系：双向孟德尔随机化分析。","authors":"Yuchao Liu, Chunli Li, Linli Yao, Yuan Tan, Lu Shi, Pei Chen","doi":"10.1007/s11682-025-00986-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.</p><p><strong>Results: </strong>Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10<sup>-4</sup>). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10<sup>-4</sup>). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).</p><p><strong>Conclusions: </strong>Specific brain activity and connectivity patterns are causally linked to tinnitus.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"456-467"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis.\",\"authors\":\"Yuchao Liu, Chunli Li, Linli Yao, Yuan Tan, Lu Shi, Pei Chen\",\"doi\":\"10.1007/s11682-025-00986-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.</p><p><strong>Results: </strong>Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10<sup>-4</sup>). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10<sup>-4</sup>). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).</p><p><strong>Conclusions: </strong>Specific brain activity and connectivity patterns are causally linked to tinnitus.</p>\",\"PeriodicalId\":9192,\"journal\":{\"name\":\"Brain Imaging and Behavior\",\"volume\":\" \",\"pages\":\"456-467\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Imaging and Behavior\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11682-025-00986-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROIMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Imaging and Behavior","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11682-025-00986-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的：耳鸣影响着全世界数百万人。其神经机制尚不清楚。本研究旨在利用孟德尔随机化（MR）分析探讨脑功能网络与耳鸣风险之间的因果关系。方法：我们使用静息状态功能磁共振成像（rs-fMRI）的大脑活动数据和全基因组关联研究（GWAS）的遗传数据进行MR分析。总共有191个大脑特征，包括振幅特征和功能连接测量，是根据它们的遗传关联选择的。结果：正向磁共振分析显示，顶叶和下额叶区域活动的增加与耳鸣风险降低41%相关（OR = 0.59, p = 1.8 × 10-4）。相比之下，楔前叶、角回和额叶区域活动增加与耳鸣风险增加49%相关（OR = 1.49, p = 8.9 × 10-4）。顶叶和下额区的活动与耳鸣风险呈负相关（OR = 0.72, p = 0.0037）。此外，顶叶、额叶和颞叶区域较高的活动使风险增加了一倍（OR = 2.02, p = 0.015）。反向MR显示，额叶和颞叶区域之间更强的连通性与耳鸣风险呈负相关（β = - 0.056, p = 0.049）。结论：特定的大脑活动和连接模式与耳鸣有因果关系。
Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis.
Objectives: Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.
Methods: We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.
Results: Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10-4). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10-4). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).
Conclusions: Specific brain activity and connectivity patterns are causally linked to tinnitus.
期刊介绍：
Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.
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