二氢香豆素对硫酸铜致吐雏鸡止吐及调节作用的体内研究

Kajal Kumari Sharma , Md. Sakib Al Hasan , Razina Rouf , Yasin Emon , Emon Mia , Rakib Hossan , Md. Arif Hossain , Md. Nasimul Haque Shipon , Muhammad Torequl Islam
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引用次数: 0

摘要

二氢香豆素(DHC)是一种天然化合物,存在于甜三叶草和红豆等植物中,通常用作食品中的调味剂和化妆品中的香料。本研究采用硫酸铜诱导的2日龄家鸡呕吐模型研究DHC的潜在止吐特性。给药剂量为12.5、25和50 mg/kg时,DHC的影响与标准止吐药进行比较;阳性对照分别口服多潘立酮(DOM, 7 mg/kg)和昂丹司琼(OND, 5 mg/kg)。结果表明,DHC显著(p <;0.05)以剂量依赖的方式降低干呕频率并延长潜伏期。在50 mg/kg剂量下,DHC达到了最高的潜伏期(54.92秒)和最大的减少干呕(24.38秒),突出了其单独的疗效。然而,当DHC (50 mg/kg)与DOM或OND同时给药时,联合治疗显示出拮抗作用,强调了潜在药物相互作用的复杂性。尽管与标准药物相比,其疗效中等,但根据经合组织指南进行的急性毒性试验显示,剂量高达1000 mg/kg时没有不良反应,表明雏鸡的LD50大于1 g/kg。DHC作为一种温和的天然止吐剂表现出了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of antiemetic and modulatory activity of dihydrocoumarin on copper sulfate induced emetic chicks: An in vivo investigation
Dihydrocoumarin (DHC) is a natural compound found in plants like sweet clover and tonka beans, commonly used as a flavoring agent in food and as a fragrance in cosmetics. This study investigates the potential antiemetic properties of DHC using a copper sulfate-induced emesis model using 2-day-old Gallus domesticus chicks. Administered at doses of 12.5, 25, and 50 mg/kg, DHC's impact was compared with standard antiemetics; domperidone (DOM, 7 mg/kg) and ondansetron (OND, 5 mg/kg) were administered orally as positive controls. Results demonstrated that DHC significantly (p < 0.05) reduced the frequency of retches and prolonged the latency period in a dose-dependent manner. At 50 mg/kg, DHC achieved the highest latency (54.92 ss) and maximum reduction in retches (24.38), highlighting its standalone efficacy. However, combination therapies revealed antagonistic effects when DHC (50 mg/kg) was co-administered with DOM or OND, emphasizing the complexity of potential drug interactions. Despite its moderate efficacy compared to standard drugs, acute toxicity testing, conducted according to OECD guidelines, revealed no adverse effects at doses up to 1000 mg/kg, suggesting an LD50 greater than 1 g/kg in chicks. DHC exhibited promise as a natural antiemetic with a milder profile.
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来源期刊
Food chemistry advances
Food chemistry advances Analytical Chemistry, Organic Chemistry, Chemistry (General), Molecular Biology
CiteScore
1.90
自引率
0.00%
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0
审稿时长
99 days
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