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IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2025-02-20 DOI:10.1002/oby.24219

Xiaoru Feng, Ruoqian Li, Hang Yi, Shuyi Chen, Meng Liu, You Wu

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引用次数: 0

摘要

目的：本研究的目的是估算超重（EBW）导致的癌症负担并确定其主要来源：本研究旨在估算超重（EBW）导致的癌症负担，并确定其主要来源：我们从荟萃分析中获得了相对风险，从《2021 年全球疾病负担研究》（GBD）中获得了癌症和人口数据，从非传染性疾病风险因素合作组织（NCD-RisC）中获得了体重指数流行率数据。我们计算了1990年至2021年因高体重指数而导致的11种癌症的发病率，利用连接点回归分析了趋势，并利用年龄-时期-队列模型评估了队列效应。根据癌症特异性风险因素以及人口规模、老龄化和流行病学变化进行了分解分析：结果：从 1990 年到 2021 年，11 种 EBW 相关癌症的发病率有所上升。出生较晚的人群和年龄较大的群体癌症发病率较高。高体重指数是导致癌症负担变化的首要因素（占所有残疾调整生命年的 15.96%），尤其是在社会人口指数（SDI）较高的地区。结直肠癌、食道癌和肝癌因高体重指数造成的负担最高（分别为1,349,622、1,284,385和944,616残疾调整生命年）。体重指数的流行病学变化导致残疾调整寿命年数负担上升，从绝经后乳腺癌的7.88%到肝癌的49.20%不等：EBW患病率的上升加重了全球癌症负担，显示出显著的出生队列效应。高体重指数是导致肥胖相关癌症的首要因素，超过了其他流行病学风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Global cancer burden attributable to excess body weight, 1990 to 2021, decomposed by population size, aging, and epidemiological change

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Global cancer burden attributable to excess body weight, 1990 to 2021, decomposed by population size, aging, and epidemiological change

Objective

The objective of this study was to estimate cancer burden attributable to excess body weight (EBW) and identify its main source.

Methods

We obtained relative risks from meta-analyses, cancer and population data from the Global Burden of Disease Study (GBD) 2021, and BMI prevalence data from the NCD Risk Factor Collaboration (NCD-RisC). We calculated the incidence of 11 cancers attributable to high BMI from 1990 to 2021, analyzed trends using joinpoint regression, and assessed cohort effects with the age-period-cohort model. Decomposition analysis was conducted by cancer-specific risk factors and by population size, aging, and epidemiological changes.

Results

The incidence of 11 EBW-related cancers has increased from 1990 to 2021. Later-born cohorts and older age groups had higher cancer incidence rates. High BMI was the top contributor to changes in cancer burden (15.96% of all disability-adjusted life years [DALYs]), particularly in high Sociodemographic Index (SDI) regions. Colorectal, esophageal, and liver cancer had the highest burden due to high BMI (1,349,622; 1,284,385; and 944,616 DALYs, respectively). Epidemiological changes in BMI contributed to the rising DALY burden, ranging from 7.88% for postmenopausal breast cancer to 49.20% for liver cancer.

Conclusions

The rising prevalence of EBW contributed to the global cancer burden, showing a significant birth cohort effect. High BMI was the top contributing factor to obesity-related cancers, surpassing other epidemiological risk factors.

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.