Sara Bassani, Paolo Tesauro, Daniele Monzani, Gabriele Molteni
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引用次数: 0
摘要
背景：分析现有文献关于头颈部鳞状细胞癌（HNSCC）的颈部清扫（ND）中淋巴结产量（LNY）作为预后因素和治疗是否充分的指示。方法：系统检索2010年1月~ 2023年6月的PubMed、EMBASE和Web of Science数据库。纳入标准包括接受ND的粘膜HNSCC患者的LNY数据及其与生存结果的关联研究。质量评估遵循REMARK指南。结果：在纳入的29项研究中，与改善生存结果相关的最小LNY阈值范围为10至36.5个淋巴结。亚位点参与和cN0/cN +状态的异质性对建立共识截止构成挑战。该综述强调需要标准化的手术技术和病理评估，以确保数据的可比性。结论：LNY是反映HNSCC ND质量的预后指标。
Defining a minimum nodal yield for neck dissection in mucosal head and neck squamous cell carcinoma, a systematic review.
Background: Analysis of existing literature on lymph node yield (LNY) in neck dissection (ND) for head and neck squamous cell carcinomas (HNSCC) used as a prognostic factor and an indication of treatment adequacy.
Methods: PubMed, EMBASE and Web of Science databases were systematically searched from January 2010 to June 2023. Inclusion criteria encompassed studies on mucosal HNSCC patients undergoing ND with data on LNY and its association with survival outcomes. The quality assessment followed the REMARK guidelines.
Results: Among 29 included studies, minimum LNY tresholds associated with improved survival outcomes ranged from 10 to 36.5 nodes. The heterogeneity in subsite involvement and cN0/cN + status constituted a challenge in establishing a consensus cutoff. The review highlights the need for standardized surgical techniques and pathological assessments to ensure data comparability.
Conclusions: LNY is a prognostic indicator and could reflect ND quality in HNSCC.
期刊介绍：
Official Journal of
European Union of Medical Specialists – ORL Section and Board
Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery
"European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level.
European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.
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