欧洲和南非感染艾滋病毒的儿童和青少年感染SARS-CoV-2的风险是否更高,COVID-19的预后是否较差?

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES
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引用次数: 0

摘要

感染艾滋病毒(CALWHIV)的儿童、青少年和年轻人(包括资源有限环境中的儿童、青少年和年轻人)感染严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)、2019冠状病毒病(COVID-19)预后较差和多系统炎症综合征(MIS)的风险可能会增加。我们在2020-2022年对欧洲(n = 493)和南非(n = 307)的CALWHIV患者以及南非(n = 100)的hiv阴性青少年进行了重复的SARS-CoV-2血清患病率调查。血液样本检测SARS-CoV-2抗体,问卷收集SARS-CoV-2危险因素和疫苗接种状况数据,并从健康记录中提取临床数据。SARS-CoV-2血清阳性率(95% CI)在欧洲CALWHIV中为55%(50%-59%),在南非CALWHIV中为67%(61%-72%),在南非hiv阴性参与者中为85%(77%-92%)。在抽样时未接种疫苗的人群中(n = 769, 85%),血清阳性率分别为40%(35%-45%)、64%(58%-70%)和81%(71%-89%)。很少有参与者(总体11%)有已知的sars - cov -2阳性PCR史或自我报告的COVID-19。3名CALWHIV住院,2名患有COVID-19(非严重疾病),1名患有MIS的年轻人。尽管SARS-CoV-2的血清阳性率在所有环境中都很高,即使在未接种疫苗的参与者中也是如此,但它与一般人群估计值大致相当,而且大多数感染是轻度/无症状的。结果支持排除COVID-19高危人群中无严重免疫抑制的CALWHIV的政策决定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are children and adolescents living with HIV in Europe and South Africa at higher risk of SARS-CoV-2 and poor COVID-19 outcomes?

Children, adolescents, and young people living with HIV (CALWHIV), including those in resource-limited settings, may be at increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, poorer coronavirus disease 2019 (COVID-19) outcomes, and multisystem inflammatory syndrome (MIS). We conducted a repeat SARS-CoV-2 seroprevalence survey among CALWHIV in Europe (n = 493) and South Africa (SA, n = 307), and HIV-negative adolescents in SA (n = 100), in 2020-2022. Blood samples were tested for SARS-CoV-2 antibody, questionnaires collected data on SARS-CoV-2 risk factors and vaccination status, and clinical data were extracted from health records. SARS-CoV-2 seroprevalence (95% CI) was 55% (50%-59%) in CALWHIV in Europe, 67% (61%-72%) in CALWHIV in SA, and 85% (77%-92%) among HIV-negative participants in SA. Among those unvaccinated at time of sampling (n = 769, 85%), seroprevalence was 40% (35%-45%), 64% (58%-70%), and 81% (71%-89%), respectively. Few participants (11% overall) had a known history of SARS-CoV-2-positive PCR or self-reported COVID-19. Three CALWHIV were hospitalized, two with COVID-19 (nonsevere disease) and one young adult with MIS. Although SARS-CoV-2 seroprevalence was high across all settings, even in unvaccinated participants, it was broadly comparable to general population estimates, and most infections were mild/asymptomatic. Results support policy decisions excluding CALWHIV without severe immunosuppression from high-risk groups for COVID-19.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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