孟德尔随机分析揭示了急性前葡萄膜炎的肠道微生物-眼睛轴。

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-02-21 DOI:10.1038/s41433-025-03715-3

Yuze Mi, Lu Chen, Na Liao, Minghui Wan

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引用次数: 0

摘要

背景：观察性研究表明，肠道微生物群（GM）可能与急性前葡萄膜炎（AAU）的发展有关，但因果关系尚不清楚。本研究旨在检验特定转基因分类群是否与AAU有因果关系。方法：从DMP中获取7738个个体的粪便样本，并分析宿主基因型与分类群丰度的关联。AAU数据来源于FinnGen Consortium（8624例和473095例对照）。我们主要采用反方差加权法，辅以敏感性分析。结果:高大量Lachnospiraceae无名(OR = 0.86, 95% CI 0.81 - -0.91, P = 5.7×换,Alistipes finegoldii (OR = 0.87, 95% CI 0.78 - -0.96, P = 0.008), Erysipelotrichaceae (OR = 0.90, 95% CI 0.81 - -0.99, P = 0.037), Erysipelotrichia (OR = 0.90, 95% CI 0.81 - -0.99, P = 0.037), Erysipelotrichales (OR = 0.90, 95% CI 0.81 - -0.99, P = 0.037),和拟杆菌ovatus (OR = 0.93, 95% CI 0.87 - -1.00, P = 0.039)预测AAU风险较低。相反，链状双歧杆菌（OR = 1.06, 95% CI: 1.02-1.10, P = 0.005）、拟杆菌（OR = 1.11, 95% CI: 1.02-1.21, P = 0.014）、未分类拟杆菌（OR = 1.12, 95% CI: 1.03-1.22, P = 0.010）和普雷沃氏菌（OR = 1.15, 95% CI: 1.01-1.29, P = 0.029）丰度较高预示AAU风险较高。结果还显示AAU与链状双歧杆菌呈反向因果关系（OR = 1.39, 95% CI: 1.03-1.86, P = 0.005）。结论：本研究提示特异性GM与AAU风险存在因果关系，需要更多的机制验证和临床试验。

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Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis.

Background: Observational studies suggest that gut microbiome (GM) may contribute to acute anterior uveitis (AAU) development, but causality remains unclear. This study was conducted to test whether specific GM taxa were causally associated with AAU.

Methods: The GM data were obtained from the DMP, which included 7738 individuals' faecal samples and an analysis of host genotype-taxa abundance associations. The AAU data were derived from the FinnGen Consortium (8624 cases and 473,095 controls). We primarily employed the inverse-variance weighted method, complemented by supplementary sensitivity analyses.

Results: Higher abundance of Lachnospiraceae noname (OR = 0.86, 95% CI 0.81-0.91, P = 5.7 × 10^-8), Alistipes finegoldii (OR = 0.87, 95% CI 0.78-0.96, P = 0.008), Erysipelotrichaceae (OR = 0.90, 95% CI 0.81-0.99, P = 0.037), Erysipelotrichia (OR = 0.90, 95% CI 0.81-0.99, P = 0.037), Erysipelotrichales (OR = 0.90, 95% CI 0.81-0.99, P = 0.037), and Bacteroides ovatus (OR = 0.93, 95% CI 0.87-1.00, P = 0.039) predicted a lower AAU risk. Conversely, higher abundance of Bifidobacterium catenulatum (OR = 1.06, 95% CI: 1.02-1.10, P = 0.005), Bacteroides coprocola (OR = 1.11, 95% CI: 1.02-1.21, P = 0.014), Parabacteroides unclassified (OR = 1.12, 95% CI 1.03-1.22, P = 0.010), and Prevotella (OR = 1.15, 95% CI: 1.01-1.29, P = 0.029) predicted a higher AAU risk. The results also showed a reverse causation from AAU to Bifidobacterium catenulatum (OR = 1.39, 95% CI: 1.03-1.86, P = 0.005).

Conclusion: This study suggests that specific GM is causally associated with AAU risk, warranting more mechanistic validation and clinical trials.

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.