Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan
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This systematic review evaluated the effect of polyphenol supplementation on adiposity in overweight adults and elderly people (Systematic Review Registration: CRD42024586193).</p><p><strong>Recent findings: </strong>Current research demonstrates that polyphenol supplementation resulted in a significant decrease in markers of central adiposity (percentage of body fat, fat mass, waist circumference) and visceral adiposity (visceral adipose tissue). The mechanisms may be involved in the activation of lipid turnover pathways, AMPK activation and suppression of transcription factors (SREBPs, PPAR-γ and C/EBP-α) and key enzymes in lipid synthesis in adipose tissue. Furthermore, polyphenol supplementation has also beneficial effects on controlling of blood pressure, blood glucose and lipid profile, contribute to the prevention of other chronic metabolic disorders. Adiposity refers to the distribution of body fat, closely related to cardiometabolic risk, while polyphenols are phytochemicals with potential health-promoting effects. However, the role of these bioactive compounds in controlling adiposity is not well established. This systematic review presents antiadipogenic and metabolic control effects of the dietary polyphenol supplementation. However, there is no consensus on a specific dosage or form of presentation that generates the best results. Further studies are needed to elucidate better the potential effect of these compounds and related-pathway, to perform clinical validation of their use, and to establish the benefits of their long-term use.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"36"},"PeriodicalIF":5.5000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials.\",\"authors\":\"Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan\",\"doi\":\"10.1007/s13668-025-00626-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>The obesity is a multifactorial disease, result of high adiposity and excessive body fat, with closed relation to the development of other chronic disease. 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Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials.
Purpose of review: The obesity is a multifactorial disease, result of high adiposity and excessive body fat, with closed relation to the development of other chronic disease. The growing obesity-related costs has relevant public health impact. In turn, the polyphenol is a dietary bioactive compound with recognized antioxidant propriety and healthy benefits. The polyphenol supplementation can be a promising strategy for obesity treatment, due to its potential antiadipogenic and metabolic control effects, improving quality of life of this population. This systematic review evaluated the effect of polyphenol supplementation on adiposity in overweight adults and elderly people (Systematic Review Registration: CRD42024586193).
Recent findings: Current research demonstrates that polyphenol supplementation resulted in a significant decrease in markers of central adiposity (percentage of body fat, fat mass, waist circumference) and visceral adiposity (visceral adipose tissue). The mechanisms may be involved in the activation of lipid turnover pathways, AMPK activation and suppression of transcription factors (SREBPs, PPAR-γ and C/EBP-α) and key enzymes in lipid synthesis in adipose tissue. Furthermore, polyphenol supplementation has also beneficial effects on controlling of blood pressure, blood glucose and lipid profile, contribute to the prevention of other chronic metabolic disorders. Adiposity refers to the distribution of body fat, closely related to cardiometabolic risk, while polyphenols are phytochemicals with potential health-promoting effects. However, the role of these bioactive compounds in controlling adiposity is not well established. This systematic review presents antiadipogenic and metabolic control effects of the dietary polyphenol supplementation. However, there is no consensus on a specific dosage or form of presentation that generates the best results. Further studies are needed to elucidate better the potential effect of these compounds and related-pathway, to perform clinical validation of their use, and to establish the benefits of their long-term use.
期刊介绍：
This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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