先进的工程纳米平台克服靶向脑肿瘤的生物屏障。

IF 2.3 4区 医学 Q3 ONCOLOGY
Shaheen Sultana, Jyoti Gupta, Vikram Sharma, Komal Gupta, Gayatri Khosla, Darshna Mishra
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引用次数: 0

摘要

有效的药物输送到大脑受到血脑屏障(BBB)的严重阻碍,血脑屏障是一种选择性屏障,使中枢神经系统(CNS)疾病(包括脑肿瘤)的治疗复杂化。最近在制药科学方面的创新引入了新的策略来克服这一挑战并提高治疗效果。本文综述了克服血脑屏障的工程纳米平台的最新进展,重点介绍了它们在脑肿瘤靶向治疗中的应用。它旨在评估不同的药物递送策略和配方,以增强大脑渗透,提高靶向精度,并最大限度地减少系统副作用。本文对脑靶向策略的相关文献和最新研究进行了综述。本文综述了延长血液循环时间的策略,并特别分析了聚乙二醇化方法、基于脂质的纳米载体、白蛋白结合策略和基于红细胞的递送。它还探索了各种策略(如肽、前药、抗体、纳米技术、基于配体的递送)和亚细胞靶向技术,旨在增强大脑药物递送和细胞摄取。聚乙二醇化通过减少巨噬细胞介导的清除,显著提高纳米载体穿透脑肿瘤的能力。基于纳米技术的策略与基于配体的方法相结合,有效地增强了脑传递。亚细胞靶向策略促进内溶酶体逃逸,导致更好的治疗药物在脑肿瘤细胞内保留。纳米技术和靶向策略的进步为克服血脑屏障和改善脑肿瘤治疗提供了有希望的解决方案。这些新策略显著增强了大脑的靶向性,同时最小化了系统效应。持续的研究对于优化这些方法和获得更有效的治疗结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advanced Engineered Nanoplatforms to Overcome Biological Barriers for Targeting Brain Tumors.

Effective drug delivery to the brain is critically hindered by the blood-brain barrier (BBB), a selective barrier that complicates treatment for central nervous system (CNS) disorders, including brain tumors. Recent innovations in pharmaceutical sciences have introduced new strategies to surmount this challenge and enhance therapeutic efficacy. This review aims to assess recent advancements in engineered nanoplatforms designed to overcome the BBB, with a focus on their application in brain tumor targeting. It seeks to evaluate different drug delivery strategies and formulations that enhance brain penetration, improve targeting precision, and minimize systemic side effects. A comprehensive review of the literature and recent studies on brain-targeting strategies was conducted. The review examined the strategies to prolong blood circulation time and analyzed particularly the PEGylation approach, lipid-based nanocarrier, albumin binding strategies and red blood cell-based delivery. It also explored various strategies (e.g., peptides, prodrug, antibodies, nanotechnology, ligand-based delivery) and subcellular targeting techniques aimed at enhancing brain drug delivery and cellular uptake. PEGylation was found to significantly improve the ability of nano carriers to penetrate brain tumors by reducing macrophage-mediated clearance. Nanotechnology-based strategies coupled with ligand-based approaches effectively enhance brain delivery. Subcellular targeting strategies facilitated endolysosomal escape, leading to better therapeutic agent retention within brain tumor cells. Advances in nanotechnology and targeting strategies offer promising solutions for overcoming the BBB and improving brain tumor treatment. These novel strategies significantly enhance brain targeting while minimizing systemic effects. Continued research is essential to optimize these methods and achieve more effective therapeutic outcomes.

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来源期刊
Current cancer drug targets
Current cancer drug targets 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
105
审稿时长
1 months
期刊介绍: Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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