低级别乳腺腺鳞癌1例报告。

IF 0.7 Q4 ONCOLOGY
Case Reports in Oncology Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI:10.1159/000542764
Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa
{"title":"低级别乳腺腺鳞癌1例报告。","authors":"Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa","doi":"10.1159/000542764","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Low-grade adenosquamous carcinoma (LGASC) is categorized as a metaplastic carcinoma but differs from other types of metaplastic carcinoma in having a more favorable prognosis. Due to its rarity and unusual and inconsistent presentation, there is little information available regarding its characteristics, making correct diagnosis a challenge.</p><p><strong>Case presentation: </strong>We report herein the case of a 54-year-old Japanese woman who presented with a lump in her left breast. She was found to have a benign lesion which continually relapsed, necessitating repeated excisions, ultimately leading to the diagnosis of LGASC after the third excision. Guidelines for the treatment of LGASC emphasize complete tumor excision, with adjuvant therapies only considered in cases with positive lymph node metastasis. Consequently, the patient underwent total mastectomy but postoperative chemotherapy was not administered, and the patient was followed up with regular observation. By 20 months postoperatively, there was no sign of recurrence.</p><p><strong>Conclusion: </strong>LGASC has distinctive pathological features of the intimate admixture of well-developed glands and solid squamous cell nests within a fibrotic or cellular spindle stroma. It is difficult to determine preoperatively with cytology or needle biopsy because LGASC mimics benign tumors. It is typically triple-negative, but it has an indolent behavior. Adjuvant therapy after surgery is considered unnecessary for triple-negative status, but there is no clear evidence. We aimed to provide more data on the disease characteristics, presentation, and treatment outcome. Accumulation of further evidence is warranted to refine diagnostic and therapeutic strategies of LGASC.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"92-99"},"PeriodicalIF":0.7000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731901/pdf/","citationCount":"0","resultStr":"{\"title\":\"Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report.\",\"authors\":\"Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa\",\"doi\":\"10.1159/000542764\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Low-grade adenosquamous carcinoma (LGASC) is categorized as a metaplastic carcinoma but differs from other types of metaplastic carcinoma in having a more favorable prognosis. Due to its rarity and unusual and inconsistent presentation, there is little information available regarding its characteristics, making correct diagnosis a challenge.</p><p><strong>Case presentation: </strong>We report herein the case of a 54-year-old Japanese woman who presented with a lump in her left breast. She was found to have a benign lesion which continually relapsed, necessitating repeated excisions, ultimately leading to the diagnosis of LGASC after the third excision. Guidelines for the treatment of LGASC emphasize complete tumor excision, with adjuvant therapies only considered in cases with positive lymph node metastasis. Consequently, the patient underwent total mastectomy but postoperative chemotherapy was not administered, and the patient was followed up with regular observation. By 20 months postoperatively, there was no sign of recurrence.</p><p><strong>Conclusion: </strong>LGASC has distinctive pathological features of the intimate admixture of well-developed glands and solid squamous cell nests within a fibrotic or cellular spindle stroma. It is difficult to determine preoperatively with cytology or needle biopsy because LGASC mimics benign tumors. It is typically triple-negative, but it has an indolent behavior. Adjuvant therapy after surgery is considered unnecessary for triple-negative status, but there is no clear evidence. We aimed to provide more data on the disease characteristics, presentation, and treatment outcome. Accumulation of further evidence is warranted to refine diagnostic and therapeutic strategies of LGASC.</p>\",\"PeriodicalId\":9625,\"journal\":{\"name\":\"Case Reports in Oncology\",\"volume\":\"18 1\",\"pages\":\"92-99\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731901/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000542764\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000542764","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

简介:低级别腺鳞癌(LGASC)被归类为化生癌,但与其他类型的化生癌不同,其预后较好。由于其罕见、不寻常和不一致的表现,关于其特征的信息很少,使正确诊断成为一项挑战。病例介绍:我们在此报告一例54岁的日本妇女,她的左乳房出现肿块。她被发现有一个良性病变,不断复发,需要多次切除,最终导致第三次切除后诊断为LGASC。LGASC的治疗指南强调完全切除肿瘤,只有在淋巴结转移阳性的情况下才考虑辅助治疗。因此,患者行全乳切除术,术后未进行化疗,并定期随访观察。术后20个月无复发迹象。结论:LGASC具有明显的病理特征,在纤维化或细胞梭形间质中有发育良好的腺体和实心鳞状细胞巢。由于LGASC与良性肿瘤相似,术前很难通过细胞学检查或穿刺活检来确定。它是典型的三阴性,但它有一个懒惰的行为。手术后的辅助治疗被认为是不必要的三阴性状态,但没有明确的证据。我们的目的是提供更多关于疾病特征、表现和治疗结果的数据。进一步的证据积累有必要完善LGASC的诊断和治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report.

Introduction: Low-grade adenosquamous carcinoma (LGASC) is categorized as a metaplastic carcinoma but differs from other types of metaplastic carcinoma in having a more favorable prognosis. Due to its rarity and unusual and inconsistent presentation, there is little information available regarding its characteristics, making correct diagnosis a challenge.

Case presentation: We report herein the case of a 54-year-old Japanese woman who presented with a lump in her left breast. She was found to have a benign lesion which continually relapsed, necessitating repeated excisions, ultimately leading to the diagnosis of LGASC after the third excision. Guidelines for the treatment of LGASC emphasize complete tumor excision, with adjuvant therapies only considered in cases with positive lymph node metastasis. Consequently, the patient underwent total mastectomy but postoperative chemotherapy was not administered, and the patient was followed up with regular observation. By 20 months postoperatively, there was no sign of recurrence.

Conclusion: LGASC has distinctive pathological features of the intimate admixture of well-developed glands and solid squamous cell nests within a fibrotic or cellular spindle stroma. It is difficult to determine preoperatively with cytology or needle biopsy because LGASC mimics benign tumors. It is typically triple-negative, but it has an indolent behavior. Adjuvant therapy after surgery is considered unnecessary for triple-negative status, but there is no clear evidence. We aimed to provide more data on the disease characteristics, presentation, and treatment outcome. Accumulation of further evidence is warranted to refine diagnostic and therapeutic strategies of LGASC.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.40
自引率
12.50%
发文量
151
审稿时长
7 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信