PIDA介导的芳基甲基酮的氧化环化：一种化学选择性合成5-取代恶唑的简便方法。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-02-13 Epub Date: 2025-02-15 DOI:10.1039/d4ob01427h

Mohankumar Devaraju , Jagadeesh Prasad Dasappa

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引用次数: 0

摘要

我们开发了一种简单有效的方案，通过取代苯乙酮与NH4OAc和DMSO氧化环，以PIDA作为有效氧化剂，化学选择性合成5-取代恶唑。NH4OAc和DMSO分别作为毒性较小的一氮和一碳合成子。它具有良好的官能团耐受性和化学选择性，是一种无金属、阶梯化和原子经济的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

PIDA mediated oxidative annulation of aryl methyl ketones: a facile approach for the chemoselective synthesis of 5-substituted oxazoles†

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PIDA mediated oxidative annulation of aryl methyl ketones: a facile approach for the chemoselective synthesis of 5-substituted oxazoles†

We have developed a simple and efficient protocol for the chemoselective synthesis of 5-substituted oxazoles via oxidative annulation of substituted acetophenones with NH₄OAc and DMSO using PIDA as an effective oxidant. NH₄OAc and DMSO act as less toxic one nitrogen and one carbon synthons, respectively. It is a metal-free, step and atom economical approach with good functional group tolerance and chemoselectivity.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.