产前压力，出生时糖皮质激素暴露的表观遗传学评估和儿童精神症状：一项前瞻性，多队列研究

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2025-02-12 DOI:10.1016/j.psyneuen.2025.107388

Nicole Creasey , Isabel Schuurmans , Stella Tsotsi , Serena Defina , Vilte Baltramonaityte , Janine F. Felix , Alexander Neumann , Christian M. Page , Marieke Tollenaar , Mona Bekkhus , Esther Walton , Charlotte Cecil

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引用次数: 0

摘要

最近的研究表明，DNA甲基化可以作为胎儿糖皮质激素暴露（MPS-GC）的一个指标，显示与妊娠期间母亲精神病理相关。然而，MPS-GC是否可以作为更广泛的产前压力的标志，以及它是否部分介导产前压力与儿童内化和外化症状的关联，目前尚不清楚。方法使用来自三个前瞻性出生队列（Npooled = 6086）的统一数据，我们检查了产前应激的累积测量及其个体应激域是否与出生时脐带血MPS-GC相关。接下来，我们研究了(i)出生时MPS-GC是否与儿童精神症状相关，（ii）这种关联是否被产后压力所调节，以及（iii）产前压力对儿童精神症状的影响是否部分由出生时MPS-GC介导。结果我们的荟萃分析显示，出生时MPS-GC与产前应激或个体应激域之间没有显著关联。此外，MPS-GC与后来的儿童内化或外化症状没有显着关联，并且没有产后压力的调节作用。此外，虽然产前压力与儿童精神症状显著相关，但我们发现出生时MPS-GC没有部分介导作用。结论：我们没有发现脐带血MPS-GC可靠地代表产前应激，与儿童精神风险相关，或部分介导产前应激和精神风险之间的关联。

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Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study

Background

Recent work suggests that DNA methylation can be used as a proxy of fetal glucocorticoid exposure (MPS-GC), showing associations with maternal psychopathology during pregnancy. However, it is unknown whether the MPS-GC may act as a marker for broader prenatal stress and whether it partially mediates associations of prenatal stress with child internalizing and externalizing symptoms.

Methods

Using harmonized data from three prospective birth cohorts (N_pooled = 6086), we examined whether a cumulative measure of prenatal stress, and its individual stress domains, associate with the MPS-GC in cord blood at birth. Next, we examined (i) whether the MPS-GC at birth associates with child psychiatric symptoms, (ii) whether this association is moderated by postnatal stress, and (iii) whether the effect of prenatal stress on child psychiatric symptoms is partially mediated by the MPS-GC at birth.

Results

Our meta-analysis revealed no significant associations between the MPS-GC at birth and prenatal stress or the individual stress domains. Moreover, the MPS-GC did not significantly associate with later child internalizing or externalizing symptoms, and there were no moderating effects of postnatal stress. Additionally, while prenatal stress significantly associated with child psychiatric symptoms, we found no partial mediation via the MPS-GC at birth.

Conclusions

We did not find support that the MPS-GC in cord blood reliably proxies prenatal stress, associates with child psychiatric risk, or partially mediates the associations between prenatal stress and psychiatric risk.

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.