胫骨股关节软骨磁化传递比与轴向压缩应变的关系

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-02-10 DOI:10.1016/j.jmbbm.2025.106937

Emily S. Sullivan , Andrew Yung , Jessica Küpper , Kirsten Bale , Piotr Kozlowski , David R. Wilson

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引用次数: 0

摘要

目的利用9.4T磁共振成像（MRI）测定牛离体软骨的磁化传递比（MTR）与应变之间的关系，并与T2与应变之间的关系进行比较。方法采用预先设计的定制电气动加载装置，在9.4T Bruker MRI扫描仪上将牛股胫骨软骨和骨软骨块压缩在一起。逐步施加载荷将软骨压缩到10%、20%和30%的应变目标。在每次负载保持恒定20分钟以最小化蠕变效应后，获得卸载软骨的图像。使用自定义算法量化接触区域的T2和MTR（平均，按深度和柱方向），并计算轴向软骨应变。采用重复测量相关性研究MTR与应变、T2与应变之间的潜在相关性。结果胫骨的平均MTR与应变相关性rrm = - 0.90 (CI = - 0.96 ~ - 0.75)，股骨的rrm = - 0.70 （CI = - 0.87 ~ - 0.35）。胫骨的平均T2与应变相关性rrm = - 0.84 (CI = - 0.94至- 0.59)，股骨的rrm = - 0.11 （CI = - 0.57至0.41）。柱式分析产生了可忽略的或弱的相关性（T2和MTR为- 0.07至- 0.34）。结论接触区smtr随应变增大而增大，MTR与应变的相关性强于T2。MTR显示了作为应变的替代测量的希望，特别是当在接触区域上平均时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Relationship between magnetization transfer ratio and axial compressive strain in tibiofemoral articular cartilage

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Relationship between magnetization transfer ratio and axial compressive strain in tibiofemoral articular cartilage

Purpose

The objective of this study was to determine the relationship between magnetization transfer ratio (MTR) and strain in ex vivo bovine cartilage using 9.4T magnetic resonance imaging (MRI) and to compare this relationship to the relationship between T2 and strain.

Methods

A previously designed custom electropneumatic loading device was used to compress together osteochondral blocks of bovine femoral and tibial cartilage and bone within a 9.4T Bruker MRI scanner. Stepwise loads were applied to compress cartilage to targets of 10%, 20% and 30% strain. Images were acquired for unloaded cartilage and after each load had been held constant for 20 min to minimize creep effects. A custom algorithm was used to quantify T2 and MTR (average, by depth, and column wise) in the region of contact, and to calculate axial cartilage strain. Repeated measures correlation was used to investigate potential correlations between MTR and strain, and T2 and strain.

Results

Mean MTR vs strain correlations were r_rm = −0.90 (CI = −0.96 to −0.75) in the tibia and r_rm = −0.70 (CI = −0.87 to −0.35) in the femur. Mean T2 vs strain correlations were r_rm = −0.84 (CI = −0.94 to −0.59) in the tibia and r_rm = −0.11 (CI = −0.57 to 0.41) in the femur. Column-wise analyses produced negligible or weak correlations (−0.07 to −0.34 for T2 and MTR).

Conclusions

MTR increases with strain in the region of contact, and MTR is more strongly correlated to strain than T2. MTR shows promise as a surrogate measure of strain, especially when averaged over the region of contact.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.