钯催化的芳基硫鎓盐选择性C-H磺化反应制备芳基砜

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-02-21 DOI:10.1021/acs.joc.4c02913

Chunjie Ni, Jin-Ping Liu, Xiao-Xu Zhang, Zi-Yi Wang, Zhanhang Liang, Chen Chen, Di Qiu

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引用次数: 0

摘要

我们提出了一个高效的钯催化的位点选择性C-H磺化反应通过芳基硫鎓盐。利用易得的芳烃和低成本的亚硫酸钠，高效地实现了C(sp2) -S交叉偶联，建立了一种可靠的合成二芳基砜的方法。该方法对官能团具有良好的耐受性，可扩展性和生物活性分子的合成或后期功能化，使其成为药物修饰的有价值的磺化工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones

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Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones

We presented a highly efficient palladium-catalyzed site-selective C–H sulfonylation reaction via aryl thianthrenium salts. By utilizing readily available and cost-effective arenes along with sodium sulfinates, we achieved the C(sp²)–S cross-coupling with high efficiency, establishing a dependable method for synthesizing diarylsulfones with satisfactory yields. This method exhibits excellent tolerance toward functional groups, scalability, and the synthesis or late-stage functionalization of bioactive molecules, making it a valuable sulfonylation tool for drug modifications.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.