A. Herrero García , S.E. Denis Filippini , A. de la Fuente , E. Choolani Bhojwani , J. Sánchez González , M. Bailón Cuadrado , S. Veleda Belanche , V. Simó Fernández , J.A. García Erce , C. Aldecoa Álvarez-Santullano
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引用次数: 0
摘要
背景：结直肠癌（CRC）是全球第三大确诊癌症。术前贫血在结直肠癌手术患者中很常见。目的：本研究评估术前贫血的患病率及其对术后结局的影响，旨在建立一个大型前瞻性单中心队列中发病率和死亡率增加的分界点。方法：对2014-2021年1105例结直肠癌患者进行回顾性队列研究。贫血是根据世卫组织标准定义的。采用多元逻辑回归和Kaplan-Meier生存分析。结果：45.3%的患者存在术前贫血，并伴有较高的围手术期并发症发生率（OR 2.76, p = 0.011）和较低的5年生存率（73% vs 87%, p）。讨论/结论：术前贫血，即使是轻微的，也与较高的并发症发生率、较长的住院时间和较高的5年死亡风险相关。
Preoperative haemoglobin as a predictor of in-hospital morbidity and 5-year mortality in colorectal cancer
Background
Colorectal cancer (CRC) is the third most diagnosed cancer worldwide. Preoperative anaemia is common in CRC patients undergoing surgery.
Objective
This study assesses the prevalence of preoperative anaemia and its impact on postoperative outcomes, and aims to establish a cut-off point for increased morbidity and mortality in a large prospective single centre cohort.
Methods
We conducted a retrospective cohort study of 1105 CRC patients (2014–2021). Anaemia was defined as per WHO criteria. Multivariate logistic regression and Kaplan-Meier survival analyses were used. The statistical significance level was set at <0.05.
Results
Preoperative anaemia was present in 45.3% of patients, and was associated with a higher incidence of perioperative complications (OR 2.76, p = 0.011) and lower 5-year survival (73% vs 87%, p < 0.001.
Discussion/conclusions
Preoperative anaemia, even when mild, is associated with a higher rate of complications, longer hospital stay, and a greater risk of 5-year mortality.
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