限时饮食、减少热量和无限制饮食对体重和新陈代谢的影响:一项随机试验。

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2025-02-19 DOI:10.1002/oby.24252
Niki Oldenburg, Douglas G. Mashek, Lisa Harnack, Qi Wang, Emily N. C. Manoogian, Nicholas Evanoff, Donald R. Dengel, Abdisa Taddese, Brad P. Yentzer, Lesia Lysne, Alison Wong, Michelle Hanson, Julie D. Anderson, Alison Alvear, Nicole LaPage, Justin Ryder, Krista Varady, Zan Gao, Suryeon Ryu, Patrick J. Bolan, Bryan Bergman, Erika Helgeson, Satchidananda Panda, Lisa S. Chow
{"title":"限时饮食、减少热量和无限制饮食对体重和新陈代谢的影响:一项随机试验。","authors":"Niki Oldenburg,&nbsp;Douglas G. Mashek,&nbsp;Lisa Harnack,&nbsp;Qi Wang,&nbsp;Emily N. C. Manoogian,&nbsp;Nicholas Evanoff,&nbsp;Donald R. Dengel,&nbsp;Abdisa Taddese,&nbsp;Brad P. Yentzer,&nbsp;Lesia Lysne,&nbsp;Alison Wong,&nbsp;Michelle Hanson,&nbsp;Julie D. Anderson,&nbsp;Alison Alvear,&nbsp;Nicole LaPage,&nbsp;Justin Ryder,&nbsp;Krista Varady,&nbsp;Zan Gao,&nbsp;Suryeon Ryu,&nbsp;Patrick J. Bolan,&nbsp;Bryan Bergman,&nbsp;Erika Helgeson,&nbsp;Satchidananda Panda,&nbsp;Lisa S. Chow","doi":"10.1002/oby.24252","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m<sup>2</sup>; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (<i>n</i> = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; <i>p</i> = 0.53) with TRE (<i>n</i> = 30) and −2.5 kg (95% CI: −5.8 to 0.8; <i>p</i> = 0.18) with CR (<i>n</i> = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"671-684"},"PeriodicalIF":4.7000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24252","citationCount":"0","resultStr":"{\"title\":\"Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial\",\"authors\":\"Niki Oldenburg,&nbsp;Douglas G. Mashek,&nbsp;Lisa Harnack,&nbsp;Qi Wang,&nbsp;Emily N. C. Manoogian,&nbsp;Nicholas Evanoff,&nbsp;Donald R. Dengel,&nbsp;Abdisa Taddese,&nbsp;Brad P. Yentzer,&nbsp;Lesia Lysne,&nbsp;Alison Wong,&nbsp;Michelle Hanson,&nbsp;Julie D. Anderson,&nbsp;Alison Alvear,&nbsp;Nicole LaPage,&nbsp;Justin Ryder,&nbsp;Krista Varady,&nbsp;Zan Gao,&nbsp;Suryeon Ryu,&nbsp;Patrick J. Bolan,&nbsp;Bryan Bergman,&nbsp;Erika Helgeson,&nbsp;Satchidananda Panda,&nbsp;Lisa S. Chow\",\"doi\":\"10.1002/oby.24252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m<sup>2</sup>; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (<i>n</i> = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; <i>p</i> = 0.53) with TRE (<i>n</i> = 30) and −2.5 kg (95% CI: −5.8 to 0.8; <i>p</i> = 0.18) with CR (<i>n</i> = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":\"33 4\",\"pages\":\"671-684\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24252\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24252\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24252","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的:代谢改善可能先于体重减轻。我们比较了自我选择的8小时限时进食(TRE)、15%热量限制(CR)和无限制进食(UE)对体重、身体成分、热量摄入、血糖测量和代谢灵活性的影响。方法:在这项为期12周的随机对照试验中,我们测量了体重(主要结果)、身体组成(双能x线吸收仪/磁共振成像)、热量摄入(24小时回忆)、代谢灵活性(高胰岛素-正血糖钳夹期间的间接量热法)和血糖测量(血红蛋白A1c、高胰岛素-正血糖钳夹、连续血糖监测)。结果:在88名入组参与者中,81名(92%)完成了试验(平均[SD],年龄,43.2[10.5]岁,BMI, 36.2 [5.1] kg/m2;54.5%女性,84.1%白人)。TRE的最终进食窗口为9.8小时(95% CI: 9.0 - 10.6), CR为12.9小时(95% CI: 11.9 - 13.9), UE为11.8小时(95% CI: 11.0 - 12.7)。与UE (n = 29)相比,体重变化为-1.4 kg (95% CI: -4.5至1.7;p = 0.53)和混乱关系(n = 30)和-2.5公斤(95%置信区间CI: -5.8 - 0.8;p = 0.18), CR (n = 29)。TRE的代谢柔韧性低于CR (-0.041 [95% CI: -0.080至-0.002])。各组之间的体重、身体组成、热量摄入和血糖测量值相似。减少进食窗口与减少热量摄入和内脏脂肪相关。结论:在为期12周的干预中,与CR或UE相比,TRE并没有导致体重、平均身体成分、血糖或代谢指标的显著改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial

Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial

Objective

Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.

Methods

In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).

Results

Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m2; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (n = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; p = 0.53) with TRE (n = 30) and −2.5 kg (95% CI: −5.8 to 0.8; p = 0.18) with CR (n = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.

Conclusions

In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信