Niki Oldenburg, Douglas G. Mashek, Lisa Harnack, Qi Wang, Emily N. C. Manoogian, Nicholas Evanoff, Donald R. Dengel, Abdisa Taddese, Brad P. Yentzer, Lesia Lysne, Alison Wong, Michelle Hanson, Julie D. Anderson, Alison Alvear, Nicole LaPage, Justin Ryder, Krista Varady, Zan Gao, Suryeon Ryu, Patrick J. Bolan, Bryan Bergman, Erika Helgeson, Satchidananda Panda, Lisa S. Chow
{"title":"限时饮食、减少热量和无限制饮食对体重和新陈代谢的影响:一项随机试验。","authors":"Niki Oldenburg, Douglas G. Mashek, Lisa Harnack, Qi Wang, Emily N. C. Manoogian, Nicholas Evanoff, Donald R. Dengel, Abdisa Taddese, Brad P. Yentzer, Lesia Lysne, Alison Wong, Michelle Hanson, Julie D. Anderson, Alison Alvear, Nicole LaPage, Justin Ryder, Krista Varady, Zan Gao, Suryeon Ryu, Patrick J. Bolan, Bryan Bergman, Erika Helgeson, Satchidananda Panda, Lisa S. Chow","doi":"10.1002/oby.24252","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m<sup>2</sup>; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (<i>n</i> = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; <i>p</i> = 0.53) with TRE (<i>n</i> = 30) and −2.5 kg (95% CI: −5.8 to 0.8; <i>p</i> = 0.18) with CR (<i>n</i> = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"671-684"},"PeriodicalIF":4.7000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24252","citationCount":"0","resultStr":"{\"title\":\"Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial\",\"authors\":\"Niki Oldenburg, Douglas G. Mashek, Lisa Harnack, Qi Wang, Emily N. C. Manoogian, Nicholas Evanoff, Donald R. Dengel, Abdisa Taddese, Brad P. Yentzer, Lesia Lysne, Alison Wong, Michelle Hanson, Julie D. Anderson, Alison Alvear, Nicole LaPage, Justin Ryder, Krista Varady, Zan Gao, Suryeon Ryu, Patrick J. Bolan, Bryan Bergman, Erika Helgeson, Satchidananda Panda, Lisa S. Chow\",\"doi\":\"10.1002/oby.24252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m<sup>2</sup>; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (<i>n</i> = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; <i>p</i> = 0.53) with TRE (<i>n</i> = 30) and −2.5 kg (95% CI: −5.8 to 0.8; <i>p</i> = 0.18) with CR (<i>n</i> = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":\"33 4\",\"pages\":\"671-684\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24252\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24252\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24252","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial
Objective
Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.
Methods
In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).
Results
Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m2; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (n = 29), weight changes were −1.4 kg (95% CI: −4.5 to 1.7; p = 0.53) with TRE (n = 30) and −2.5 kg (95% CI: −5.8 to 0.8; p = 0.18) with CR (n = 29). TRE showed lower metabolic flexibility than CR (−0.041 [95% CI: −0.080 to −0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.
Conclusions
In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.
期刊介绍:
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.