Canada HARMONY Study: Improvements in Patient Satisfaction With Facial Appearance and Psychological Impact of Combined Aesthetic Treatment.

Background: Panfacial treatment has the potential to positively impact psychosocial and emotional well-being.

Objectives: The Canada HARMONY study evaluated the satisfaction and psychosocial impact of comprehensive, multimodal aesthetic treatment of the face and submental area from the patient perspective.

Methods: Over 12 months, all patients (N = 58) sequentially received treatment with hyaluronic acid (HA) fillers, onabotulinumtoxinA, and medical-grade skincare products, and eligible patients (n = 13) also received ATX-101. The primary endpoint was the change from baseline on the FACE-Q Satisfaction with Facial Appearance Scale. Secondary endpoints included the following assessments: FACE-Q Expectations of Life Change, Psychological Function, Social Function, Satisfaction with Skin, and Aging Appraisal Scales; Global Aesthetic Improvement Scale (GAIS); and the Periorbital Aesthetic Appearance Questionnaire (PAAQ). Safety was monitored throughout the study.

Results: Baseline FACE-Q Expectations of Life Change scores indicated realistic treatment expectations. Significant improvements from baseline were observed on the FACE-Q Satisfaction with Facial Appearance, Psychological Function, Social Function, Satisfaction with Skin, and Aging Appraisal Scales (P < .0001 for all endpoints). Most patients rated "much improved" on the GAIS. The mean PAAQ total score significantly improved from baseline by 32.6 (P < .0001). Most patients reported mild-to-moderate injection-site responses, which had a mean time to resolution of <14 days.

Conclusions: Panfacial aesthetic treatment consisting of HA fillers, onabotulinumtoxinA, and ATX-101 improved patient-reported satisfaction, psychological function, social function, and aging appraisal across validated measures.

Level of evidence 5 therapeutic: