运动员中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和全身免疫炎症指数的参考区间建立：性别和运动类型影响分析

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2025-02-20 DOI:10.1002/jcla.70005

Cong Wang, Zhengmei Ning, Qi Lu, Jianya Huang, Guoqing Yuan, Junfei Chen, Gang Liu

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引用次数: 0

摘要

目的：建立运动员中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）的性别和运动特异性参考区间（RIs）。方法：回顾性分析2018-2024年13647名优秀运动员参赛作品，按性别和6个运动项目分类。RIs使用一个训练集（9555个条目）开发，并使用一个单独的集（4092个条目）进行验证。RIs使用分布的第2.5和97.5百分位来定义。结果：女性的RIs高于男性：NLR(女性：1.53 [0.74,3.25]；男性：1.36 [0.70,2.89])，PLR(女性：124 [69,223]；男性：111例[65,188])，女性：347例[146,804例]；结论：这些性别和运动特异性RIs提高了健康评估的准确性，支持运动员早期发现过度训练和炎症。未来的研究应该扩展到不同的人群，并考虑年龄和训练周期等因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reference Interval Establishment for Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Athletes: Analysis of Sex and Sport Type Impact

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Reference Interval Establishment for Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Athletes: Analysis of Sex and Sport Type Impact

Objective

To establish sex- and sport-specific reference intervals (RIs) for the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) in athletes.

Methods

A retrospective study analyzed 13,647 entries from elite athletes (2018–2024), categorized by sex and six sport types. RIs were developed using a training set (9555 entries) and validated with a separate set (4092 entries). The RIs were defined using the 2.5th and 97.5th percentiles of the distribution.

Results

Females had higher RIs compared to males: NLR (females: 1.53 [0.74, 3.25]; males: 1.36 [0.70, 2.89]), PLR (females: 124 [69, 223]; males: 111 [65, 188]), and SII (females: 347 [146, 804]; males: 298 [139, 684]) (p < 0.001). Sport type influenced RIs, with significant differences noted across categories (p < 0.001). Validation showed an outlier rate below 10% across all groups, confirming robustness.

Conclusion

These sex- and sport-specific RIs enhance the precision of health assessments, supporting early detection of overtraining and inflammation in athletes. Future studies should expand to diverse populations and consider factors like age and training cycles.

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.