口服不可吸收性抗生素预防复发性胆管炎一个简短的报告研究。

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI:10.1007/s15010-025-02491-2

Jesús Fortún, Miguel Angel Rodríguez-Gandía, Vicente Pintado, Pilar Martín-Dávila, Miguel García-González, Javier Graus, Rosa Martín-Mateos, Javier Sáez de la Fuente, Alfonso Muriel, Santiago Moreno

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引用次数: 0

摘要

背景：复发性胆管炎患者有发展为危及生命的败血症的危险。选择性去污消化道（SDD）涉及口服不可吸收抗生素已主要应用于儿童接受Kasai门肠造口手术。方法：本研究对8例复发性胆管炎患者给予含有粘菌素、妥布霉素、制霉菌素的SDD，分析SDD给药前后的发病率密度。结果：SDD期间需要住院的胆管炎总发病率密度为0.37 / 100患者日，显著低于SDD给药前的1.05 / 100患者日[RR: 0.35 (95% CI: 0.21-0.59)；结论：在本研究中，SDD降低了65%复发性胆管炎的频率和严重程度。此外，该过程对患者友好，微生物安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral nonabsorbable antibiotics for prevention of recurrent cholangitis; a brief report study.

Background: Patients with recurrent cholangitis are at risk of developing life-threatening sepsis. Selective decontamination of the digestive tract (SDD) involving oral nonabsorbable antibiotics has been primarily applied to children undergoing Kasai portoenterostomy surgery.

Methods: In this study, SDD containing colistin, tobramycin, and nystatin was administered to eight patients with recurrent cholangitis, and the incidence density before and after SDD administration was analyzed.

Results: The overall incidence density of cholangitis requiring hospital admission was 0.37 per 100 patient days during the SDD period and was significantly lower than observed before SDD administration (1.05 per 100 patient days) [RR: 0.35 (95% CI: 0.21-0.59); p: <0.001, two-sided]. This was not associated with an increased risk of resistance during SDD administration.

Conclusion: In this study SDD reduced by 65% the frequency and severity of recurrent cholangitis. In addition, this procedure is patient-friendly and microbiologically safe.

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.