创伤后应激障碍与2型糖尿病的因果关系。

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-02-19 DOI:10.1186/s13098-025-01630-x

Yuqing Song, Ancha Baranova, Hongbao Cao, Weihua Yue, Fuquan Zhang

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引用次数: 0

摘要

创伤后应激障碍（PTSD）患者与2型糖尿病（T2D）的合并症很高。创伤后应激障碍是否会影响患糖尿病的风险尚不清楚。我们使用来自欧洲血统PTSD（23,121例，151,447例对照）和T2D（80,154例，853,816例对照）的GWAS数据，通过孟德尔随机化（MR）分析来研究PTSD和T2D之间的双向关联。我们发现PTSD与较高的T2D发生率有因果关系（OR = 1.04, 95% CI: 1.01-1.06, P = 0.0086），反之则无因果关系。我们的研究表明，PTSD可能会增加患T2D的风险。PTSD患者应该接受T2D及其前兆代谢综合征的筛查。

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Causal associations between posttraumatic stress disorder and type 2 diabetes.

Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PTSD (23,121 cases and 151,447 controls) and T2D (80,154 cases and 853,816 controls) to investigate the bidirectional associations between PTSD and T2D by the Mendelian randomization (MR) analysis. We showed that PTSD was causally associated with higher odds of T2D (OR = 1.04, 95% CI: 1.01-1.06, P = 0.0086), but not vice versa. Our study suggests that PTSD may increase the risk of T2D. PTSD sufferers should be screened for T2D and its precursor known as metabolic syndrome.

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.