肢端肥大症患者的血液流变学和全身氧化状态。

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2024-10-29 DOI:10.1177/0006355X241290980

Emine Kilic-Toprak, Guzin Fidan Yaylali, Yasin Ozdemir, Senay Topsakal, Ozgen Kilic-Erkek, Burak Oymak, Melek Bor-Kucukatay

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引用次数: 0

摘要

背景：已知肢端肥大症会影响心血管系统。然而，到目前为止还没有关于血液流变学是否也发生改变的报道，关于肢端肥大症患者全身氧化状态的数据也有限。目的：探讨肢端肥大症患者血液流变学和全身氧化应激的变化。方法：选取19例主动肢端肥大症（AA）患者和15例对照肢端肥大症（CA）患者（n = 34，平均年龄48.85±1.69岁）和29例对照组（平均年龄52.83±1.37岁）。红细胞聚集指数（AI）、聚集半衰期（t½）、幅度（Amp）和红细胞延伸指数（EI）用细胞计数仪测定。采用市售试剂盒测定血清总氧化状态（TOS）和总抗氧化状态（TAS），计算氧化应激指数（OSI）。结果：在剪切应力16.87 ve 30.00 Pa时，EI （p = 0.034, p = 0.0001）和AI （p = 0.050, p = 0.035）在对照组、AA组和CA组之间差异均有统计学意义。t 1 / 2的减少与AI的增加一致，表明红细胞聚集增加。对照组、AA组和CA组血清TOS、TAS和OSI值相似（p < 0.05）。结论：这项初步研究表明，AA和CA患者红细胞变形性降低，红细胞聚集性增加。

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Blood rheology and systemic oxidative status in patients with acromegaly.

Background: Cardiovascular system is known to be affected in acromegaly. However, it was not reported to date if hemorheology was also altered and there is limited data regarding systemic oxidative status in patients with acromegaly.

Objective: To investigate alterations in hemorheology and systemic oxidative stress in patients with acromegaly.

Methods: The study comprised 19 active (AA) and 15 controlled (CA) acromegaly patients (n = 34, mean age 48.85 ± 1.69 years) and 29 controls (mean age 52.83 ± 1.37 years). Erythrocyte aggregation index (AI), aggregation half time (t½), amplitude (Amp) and erythrocyte elongation index (EI) were determined by an ektacytometer. Commercial kits were used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS), and oxidative stress index (OSI) was calculated.

Results: There were statistically significant differences regarding EI at shear stresses of 16.87 ve 30.00 Pa (p = 0.034, p = 0.0001, respectively) and AI (p = 0.050, p = 0.035, respectively) values among the control, AA and CA groups. Decrement of t½ was in line with increment of AI and indicated increased erythrocyte aggregation. Serum TOS, TAS and OSI values were similar between the control, AA and CA groups (p > 0.05).

Conclusions: This pilot study demonstrated reduced erythrocyte deformability and increased erythrocyte aggregation in patients with AA and CA.

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.