瘦肉和肥胖黎巴嫩人的肠道菌群组成。

IF 3 4区 医学 Q2 MICROBIOLOGY
M Abou-Samra, K Venema, C Ayoub Moubareck, M Karavetian
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引用次数: 0

摘要

改变的肠道微生物群已被证明有助于代谢疾病的发展,如肥胖。在本研究中,通过分离粪便样本16S rRNA V3-V4区域的DNA和测序,对30名肥胖和23名瘦弱黎巴嫩人的肠道微生物群进行了分析。瘦子组verrucomum microbiota丰度较高,肥胖组和瘦子组Bacillota/ Bacteroidota比值无显著差异。瘦肉组的均匀度和Shannon α多样性指数显著高于肥胖组(q = 0.012和q = 0.030)。基于未加权uniFrac距离变异性,肥胖组的β多样性更高(q = 0.047)。肥胖人群中只有毛杆菌属(Lachnoclostridium)的丰度较高(q = 0.013),且与饮食引起的肥胖有关,而胃球菌属(Peptococcus)、瘤胃球菌属(Ruminococcus_2)、毛杆菌科(Lachnospiraceae) UCG-001、瘤胃球菌科(Ruminococcaceae) UCG-005、瘤胃球菌科(Ruminococcaceae) UCG-010和草酸杆菌属(Oxalobacter)的丰度显著高于瘦人群。这些细菌在瘦人体内含量较高,通过产生短链脂肪酸具有抗炎特性,与较低的体重指数有关,促进饱腹感和体重减轻,可能在预防肥胖和2型糖尿病方面发挥作用。需要进一步的研究来清楚地了解肠道微生物群与健康之间的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut microbiota composition of lean and obese Lebanese individuals.

An altered gut microbiota has been shown to contribute to the development of metabolic diseases such as obesity. In this study gut microbiota profile of 30 obese and 23 lean Lebanese individuals was performed via DNA isolation and sequencing of the V3-V4 region of the 16S rRNA of faecal samples. The abundance of the phylum Verrucomicrobiota was higher in lean subjects and there was no significant difference in the Bacillota/ Bacteroidota ratio between the obese and lean groups. The evenness and Shannon alpha diversity indices were significantly higher in the lean group than in the obese group ( q = 0.012 and q = 0.030, respectively). Beta diversity was higher in the obese group based for unweighted uniFrac distance variability ( q = 0.047). Lachnoclostridium was the only genus that was higher in obese ( q = 0.013) and it is linked to diet induced obesity, while the abundance of the genera Peptococcus, Ruminococcus_2, Lachnospiraceae UCG-001, Ruminiclostridium 6, the uncharacterised taxon within Coriobacteriaceae, Ruminococcaceae UCG-005, Ruminococcaceae UCG-010 and Oxalobacter, were significantly higher in lean subjects. These bacterial species that were higher in lean people, possess anti-inflammatory properties through the production of short chain fatty acids and are linked with lower body mass index, promote satiety and weight loss and may play a role in the protection against obesity and type 2 diabetes. Further research to generate a clear understanding of the interaction of the gut microbiota and health is needed.

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来源期刊
Beneficial microbes
Beneficial microbes MICROBIOLOGY-NUTRITION & DIETETICS
CiteScore
7.90
自引率
1.90%
发文量
53
审稿时长
>12 weeks
期刊介绍: Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators. The journal will have five major sections: * Food, nutrition and health * Animal nutrition * Processing and application * Regulatory & safety aspects * Medical & health applications In these sections, topics dealt with by Beneficial Microbes include: * Worldwide safety and regulatory issues * Human and animal nutrition and health effects * Latest discoveries in mechanistic studies and screening methods to unravel mode of action * Host physiology related to allergy, inflammation, obesity, etc. * Trends in application of (meta)genomics, proteomics and metabolomics * New developments in how processing optimizes pro- & prebiotics for application * Bacterial physiology related to health benefits
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